Rui Zhao - Department of Pharmaceutical Engineering, College of Life Science & Biotechnology, Heilongjiang August First Land Reclamation University, Daqing High-Tech Industrial Development Zone, ۱۶۳۳۱۹, P.R. China
Wenli Hao - Department of Pharmaceutical Engineering, College of Life Science & Biotechnology, Heilongjiang Bayi Agricultural University, Daqing High-Tech Industrial Development Zone, ۱۶۳۳۱۹, P.R. China
Baoling Ma - Department of physical education, Hebei Normal University of Science and Technology, ۳۶۰ Hebei Street, Qinhuangdao ۰۶۶۰۰۴, P.R. China
Zhibao Chen - Department of Pharmaceutical Engineering, College of Life Science & Biotechnology, Heilongjiang Bayi Agricultural University, Daqing High-Tech Industrial Development Zone, ۱۶۳۳۱۹, P.R. China

Objective(s):Sub-health has been described as a chronic condition of unexplained deteriorated physiological function, which falls between health and illness. In the present study, we evaluated the effects of Lycium barbarum polysaccharide (LBP), a polysaccharide fraction purified from Lycium barbarum (L. barbarum) on the sub-health mice. Materials and Methods:The sub-health model mice were built through compound factors. The mice were given intragastric administration of LBP at low dose (۵۰ mg•kg-۱) and high dose (۱۰۰ mg•kg-۱), respectively. After LBP treatment for ۴ weeks, the antioxidant ability, enhancing immune function and anti-fatigue activity were detected. Results:The results showed that LBP could enhance antioxidant ability in sub-health mice. LBP could effectively improve immunity of sub-health mice and protect the immune organs, such as thymus. In addition, LBP showed anti-fatigue ability in sub-health mice. Conclusion:LBP could improve sub-health state caused from composite factor through three aspects, such as increasing antioxidant ability, promoting T lymphocyte proliferation, inhibiting thymus lymphocyte apoptosis, and alleviating fatigue.

Anti-fatigue, Antioxidant, Immunity, Lycium bararum, Polysaccharide, Sub-health