Analgesic and Anti-inflammatory Activity of Teucrium chamaedrys Leaves Aqueous Extract in Male Rats

Objective(s) Current study was undertaken to investigate the analgesic and anti-inflammatory effects of the aqueous extract of Teucrium chamaedrys in mice and rats. Materials and Methods For evaluating of analgesic and anti-inflammatory activity, we used the carrageenan- and dextran-induced paw oedema, acetic acid-induced writhing, tail flick and formalin pain tests. Results The extract of T. chamaedrys (۵۰-۲۰۰ mg/kg) and acetylsalicylic acid (۱۰۰ mg/kg) produced a significant (P< ۰.۰۱) inhibition of the second phase response in the formalin pain model, while only the high dose (۲۰۰ mg/kg) of the extract showed an analgesic effect in the first phase. The extract also inhibited acetic acid-induced abdominal writhes in a dose-dependent manner. The tail flick latency was dose dependently enhanced by the extract but this was significantly (P< ۰.۰۵) lower than that produced by morphine (۱۰ mg/kg). The extract (۲۵-۲۵۰ mg/kg) administered ۱ hr before carrageenan-induced paw swelling produced a dose dependent inhibition of the oedema. No effect was observed with the dextran-induced oedema model. Results of the phytochemical screening show the presence of alkaloids, flavonoids and triterpenoids in the extract. Conclusion The data obtained also suggest that the anti-inflammatory and analgesic effects of the extract may be mediated via both peripheral and central mechanisms. The role of alkaloids, flavonoids and triterpenoids will evaluate in future studies.

Keywords:

Analgesic , Anti-inflammatory , Formalin test , Tail flick , Teucrium chamaedrys