Resveratrol protects against diet-induced atherosclerosis by reducing low-density lipoprotein cholesterol and inhibiting inflammation in apolipoprotein E-deficient mice

Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
View: 120

This Paper With 9 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_IJBMS-18-11_002

تاریخ نمایه سازی: 3 آبان 1400

Abstract:

Objective(s):Resveratrol (RES) is a polyphenol compound that has been shown a promising cardioprotective effect. However, some reports have yielded conflicting findings. Herein, we investigated the anti-atherosclerotic effects of RES in apolipoprotein E (apo E)-deficient mice on a high cholesterol diet. Materials and Methods: Firstly, atherosclerosis was induced by feeding a high cholesterol diet to apo E-deficient mice. Then, we examined its effects on weight control, and serum interleukin-۶ (IL-۶) levels and used histopathological methods to analyze morphology and inflammatory marker of atherosclerotic lesions in mice orally supplemented with high (۲۵ mg/kg/day) and low (۵ mg/kg/day) doses of RES for ۸ weeks. Results: Mice with high dose of RES had reduced epididymal fat pads, and lower serum IL-۶ levels compared with those of control mice. Moreover, RES in high doses also decreased the low-density lipoprotein cholesterol (LDL-C) levels and atherogenic index (LDL-C/HDL-C) in the mice. Dissection of high-dose RES-treated mice revealed a marked reduction in fat deposition, percentage of mice with atherosclerotic lesion, and intima/media ratio in the aortic areas.Theexpressions of macrophage-specific marker F۴/۸۰ and cardiovascular inflammatory marker NF-κB in atherosclerotic vessels were both diminished in the atherosclerotic vessels of high-dose RES-supplementated apo E-deficient mice. Conclusion: These results suggest that RES prevented the effects of a high cholesterol diet onthe rate of accretion in atherosclerosis progression by reducing the LDL-C levels and suppressing atherosclerotic inflammation. RES can therefore be valuable in the development of new anti-atherosclerotic agents.

Authors

Geng-Ruei Chang

Department of Veterinary Medicine, National Chung Hsing University, ۲۵۰ Kuo Kuang Road, Taichung, Taiwan, ۴۰۲۲۷, R.O.C

Po-Lin Chen

Department of Veterinary Medicine, National Chung Hsing University, ۲۵۰ Kuo Kuang Road, Taichung, Taiwan, ۴۰۲۲۷, R.O.C

Po-Hsun Hou

Department of Veterinary Medicine, National Chung Hsing University, ۲۵۰ Kuo Kuang Road, Taichung, Taiwan, ۴۰۲۲۷, R.O.C

Frank Chiahung Mao

Department of Veterinary Medicine, National Chung Hsing University, ۲۵۰ Kuo Kuang Road, Taichung, Taiwan, ۴۰۲۲۷, R.O.C

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
  • Antoniadis CA, Tousoulis D. Gene therapy and coronary artery disease. ...
  • Lim S, Despres JP, Koh KK. Prevention of atherosclerosis in ...
  • Bernberg E, Ulleryd MA, Johansson ME, Bergström GM. Social disruption ...
  • Mueller MA, Beutner F, Teupser D, Ceglarek U, Thiery J. ...
  • Schachinger V, Britten MB, Zeiher AM. Prognostic impact of coronary ...
  • Rott D, Zhu J, Burnett MS, Zhou YF, Zalles-Ganley A, ...
  • Antman EM, Bennett JS, Daugherty A, Furberg C, Roberts H, ...
  • Sahebkar A, Watts GF. New LDL-cholesterol lowering therapies: pharmacology, clinical ...
  • Sahebkara A, Chew GT, Watts GF. Recent advances in pharmacotherapy ...
  • Fremont L. Biological effects of resveratrol. Life Sci ۲۰۰۰; ۶۶:۶۶۳-۶۷۳ ...
  • Yao J, Wang JY, Liu L, Li YX, Xun AY, ...
  • Udenigwe CC, Ramprasath VR, Aluko RE, Jones PJ. Potential of ...
  • Milde J, Elstner EF, Grabmann J. Synergistic effects of polyphenols ...
  • Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in ...
  • Liu K, Zhou R, Wang B, Mi MT. Effect of ...
  • Hausenblas HA, Schoulda JA, Smoliga JM. Resveratrol treatment as an ...
  • Bradamante S, Barenghi L, Villa A. Cardiovascular protective effects of ...
  • Penumathsa SV, Thirunavukkarasu M, Koneru S, Juhasz B, Zhan L, ...
  • Fan E, Zhang L, Jiang S, Bai Y. Beneficial effects ...
  • Shigematsu S, Ishida S, Hara M, Takahashi N, Yoshimatsu H, ...
  • Turrens JF, Lariccia J, Nair MG. Resveratrol has no effect ...
  • Wang Z, Zou J, Huang Y, Cao K, Xu Y, ...
  • Wilson T, Knight TJ, Beitz DC, Lewis DS, Engen RL. ...
  • Cignarella A, Minici C, Bolego C, Pinna C, Sanvito P, ...
  • Saeed O, Otsuka F, Polavarapu R, Karmali V, Weiss D, ...
  • Weiss D, Kools JJ, Taylor WR. Angiotensin II-induced hypertension accelerates ...
  • Habets KL, van Puijvelde GH, van Duivenvoorde LM , van ...
  • von der Thusen JH, van Berkel TJ, Biessen EA. Induction ...
  • Schmidt R, Bültmann A, Fischel S, Gillitzer A, Cullen P, ...
  • Chan YC, Chang SC, Liu SY, Yang HL, Hseu YC, ...
  • Macarulla MT, Alberdi G, Gómez S, Tueros I, Bald C, ...
  • Chang GR, Chiu YS, Wu YY, WY Chen, Liao JW, ...
  • Chang GR, Wu YY, Chiu YS, Chen WY, Liao JW, ...
  • Rayalam S, Yang JY, Ambati S, Della-Fera MA, Baile CA. ...
  • Kim S, Jin Y, Choi Y, Park T. Resveratrol exerts ...
  • Majumdar AS, Giri PR, Pai SA. Resveratrol- and melatonin-abated ovariectomy ...
  • Libby P, Ridker PM, Attilio Maseri. Inflammation and Atherosclerosis. Circulation ...
  • Zhong M, Cheng GF, Wang WJ, Guo Y, Zhu XY, ...
  • Mora S, Szklo M, Otvos JD, Greenland P, Psaty BM, ...
  • Chen S, Zhao X, Ran L, Wan J, Wang X, ...
  • Sahebkar A. Effects of resveratrol supplementation on plasma lipids: a ...
  • Durrington PN, Mackness B, Mackness MI. Paraoxonase and atherosclerosis. Arterioscler ...
  • Zern TL, West KL, Fernandez ML. Grape polyphenols decrease plasma ...
  • Do GM, Kwon EY, Kim HJ, Jeon SM, Ha TY, ...
  • Basu M, Prasad R, Jayamurthy P, Pal K, Arumughan C, ...
  • Chen Q, Wang E, Ma L, Zhai P. Dietary resveratrol ...
  • Chinetti G, Lestavel S, Bocher V, Remaley AT, Neve B, ...
  • Nakata R, Takahashim S, Inoue H. Recent advances in the ...
  • Williams KJ, Tabas I. The response-to-retention hypothesis of early atherogenesis. ...
  • Shankar S, Singh G, Srivastava RK. Chemoprevention by resveratrol: molecular ...
  • Culpitt SV, Rogers DF, Fenwick PS, Shah P, De Matos ...
  • Magyar K, Halmosi R, Palfi A, Feher G, Czopf L, ...
  • Fukuhara K, Miyata N. Resveratrol as a new type of ...
  • نمایش کامل مراجع