Resveratrol protects against diet-induced atherosclerosis by reducing low-density lipoprotein cholesterol and inhibiting inflammation in apolipoprotein E-deficient mice
Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-18-11_002
تاریخ نمایه سازی: 3 آبان 1400
Abstract:
Objective(s):Resveratrol (RES) is a polyphenol compound that has been shown a promising cardioprotective effect. However, some reports have yielded conflicting findings. Herein, we investigated the anti-atherosclerotic effects of RES in apolipoprotein E (apo E)-deficient mice on a high cholesterol diet. Materials and Methods: Firstly, atherosclerosis was induced by feeding a high cholesterol diet to apo E-deficient mice. Then, we examined its effects on weight control, and serum interleukin-۶ (IL-۶) levels and used histopathological methods to analyze morphology and inflammatory marker of atherosclerotic lesions in mice orally supplemented with high (۲۵ mg/kg/day) and low (۵ mg/kg/day) doses of RES for ۸ weeks. Results: Mice with high dose of RES had reduced epididymal fat pads, and lower serum IL-۶ levels compared with those of control mice. Moreover, RES in high doses also decreased the low-density lipoprotein cholesterol (LDL-C) levels and atherogenic index (LDL-C/HDL-C) in the mice. Dissection of high-dose RES-treated mice revealed a marked reduction in fat deposition, percentage of mice with atherosclerotic lesion, and intima/media ratio in the aortic areas.Theexpressions of macrophage-specific marker F۴/۸۰ and cardiovascular inflammatory marker NF-κB in atherosclerotic vessels were both diminished in the atherosclerotic vessels of high-dose RES-supplementated apo E-deficient mice. Conclusion: These results suggest that RES prevented the effects of a high cholesterol diet onthe rate of accretion in atherosclerosis progression by reducing the LDL-C levels and suppressing atherosclerotic inflammation. RES can therefore be valuable in the development of new anti-atherosclerotic agents.
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Authors
Geng-Ruei Chang
Department of Veterinary Medicine, National Chung Hsing University, ۲۵۰ Kuo Kuang Road, Taichung, Taiwan, ۴۰۲۲۷, R.O.C
Po-Lin Chen
Department of Veterinary Medicine, National Chung Hsing University, ۲۵۰ Kuo Kuang Road, Taichung, Taiwan, ۴۰۲۲۷, R.O.C
Po-Hsun Hou
Department of Veterinary Medicine, National Chung Hsing University, ۲۵۰ Kuo Kuang Road, Taichung, Taiwan, ۴۰۲۲۷, R.O.C
Frank Chiahung Mao
Department of Veterinary Medicine, National Chung Hsing University, ۲۵۰ Kuo Kuang Road, Taichung, Taiwan, ۴۰۲۲۷, R.O.C
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