The Effect of Sun Radiation on the Course of Cutaneous Leishmaniasis in BALB/c Mice
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 14، Issue: 2
Publish Year: 1390
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-14-2_007
تاریخ نمایه سازی: 3 آبان 1400
Abstract:
Objective(s) Studies have described immunomedulatory effects of sun exposure and ultraviolet radiation on infectious and neoplastic diseases. Here the effect of exposure to low potency radiation of sun on the course of leishmaniasis in mice was studied. Materials and Methods Fifteen BALB/c mice were exposed to suberythemogenic doses of sun (mean ۱۸۰ mJ/cm۲/day of UVB) ۲ months before and ۴ months after Leishmania major inoculation to food pad. Control group was kept in the sun protected environment. From ۲nd to ۱۷th week after inoculation, size of the lesion was recorded in each group weekly and at last week the parasite burden in spleen was detected. Results were compared between two groups. Results Seven mice from case group and ۹ mice from control group survived up to last week. The mean lesion size was ۰.۹۰±۰.۵۹ cm in exposed and ۴.۰۱±۳.۵۹ cm in unexposed mice (P= ۰.۰۳۷). Parasite burden in spleen of case and control groups were ۵.۵±۴.۶۱ and ۱۰۶.۹۴±۲۷۹.۷۶ respectively (P= ۰.۰۰۶). Conclusion Chronic exposure of BALB/c mice to suberythemogenic doses of sun suppressed skin lesion and decreased the extension of L. major to spleen.
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Authors
Fateme Hoseinipoor
Department of Dermatology, Emamreza Hospital, Mashhad, Iran
Mahnaz Banihashemi
Department of Dermatology, Gaem Hospital, Mashhad, Iran
Mohammad Reza Jaafari
Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Zari Javidi
Department of Dermatology, Emamreza Hospital, Mashhad, Iran
Amir Abas Azarian
Mashhad University of Medical Sciences, Mashhad, Iran
Vahid Mashayekhi Goyonlo
Department of Dermatology, Emamreza Hospital, Mashhad, Iran
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