Publisher of Iranian Journals and Conference Proceedings

Please waite ..
Publisher of Iranian Journals and Conference Proceedings
Login |Register |Help |عضویت کتابخانه ها
Paper
Title

Production of of Ibuprofen Pellets Containing High Amount of Rate Retarding Eudragit RL Using PEG۴۰۰ and Investigation of Their Physicomechanical Properties

Year: 1390
COI: JR_IJBMS-14-4_011
Language: EnglishView: 50
This Paper With 8 Page And PDF Format Ready To Download

Buy and Download

با استفاده از پرداخت اینترنتی بسیار سریع و ساده می توانید اصل این Paper را که دارای 8 صفحه است به صورت فایل PDF در اختیار داشته باشید.
آدرس ایمیل خود را در کادر زیر وارد نمایید:

Authors

Fatemeh Sadeghi - Pharmaceutical Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Hasan Hijazi - School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Hadi Afrasiabi Garekani - Pharmaceutical Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract:

Objective(s) The aim of this study was to investigate the possibility of production of ibuprofen pellets with high amount of rate retarding polymer by aid of PEG۴۰۰ as plasticizer. Materials and Methods Polyethylene glycol (PEG۴۰۰) in concentrations of ۱, ۳ or ۵% w/w with respect to Eudragit RL was used in production of pellets containing ۶۰% ibuprofen and ۴۰% excipient (۲% polyvinylpyrrolidone (PVP), ۷.۶ or ۰% microcrystalline cellulose (MCC) and ۳۰.۴ or ۳۸% Eudragit RL). Physicomechanical and release properties of pellets were evaluated. Results In presence of PEG۴۰۰, formulations containing ۳۰.۴% Eudragit RL and ۷.۶% MCC could easily form pellets. In formulations without any MCC pellets were obtained only in presence of ۳ or ۵% PEG۴۰۰. Pellets containing MCC with ۰ or ۱% PEG۴۰۰ showed brittle properties but those with ۳% or ۵% PEG۴۰۰ showed plastic nature under pressure. Elastic modulus dramatically decreased with increasing PEG۴۰۰ indicating softening of pellets. This was due to shift of Eudragit structure from glassy to rubbery state which was supported by DSC studies. Mean dissolution time (MDT) increased with addition of ۱ or ۳% PEG۴۰۰ but this was not the case for pellets with ۵% PEG۴۰۰. Conclusion Overall PEG۴۰۰ is a potential plasticizer in production of pellets based on Eudragit RL and ibuprofen. The ease in process of extrusion-spheronization, increasing the mean dissolution time and change in mechanical properties of pellets from brittle to plastic behavior were advantages of using PEG۴۰۰. Changes in mechanical properties of pellets are important when pellets are intended to be compressed as tablets.

Keywords:

Paper COI Code

This Paper COI Code is JR_IJBMS-14-4_011. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1297003/

How to Cite to This Paper:

If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Sadeghi, Fatemeh and Hijazi, Hasan and Afrasiabi Garekani, Hadi,1390,Production of of Ibuprofen Pellets Containing High Amount of Rate Retarding Eudragit RL Using PEG۴۰۰ and Investigation of Their Physicomechanical Properties,https://civilica.com/doc/1297003

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :

  • ۱.Tho I, Arne Sande S, Kleinbudde P. Pectinic acid a ...
  • ۳.Abbaspour MR, Sadeghi F, Afrasiabi Garekani H. Preperation and characterization ...
  • ۴.Santos H, Veign F, Pina M, Podczeck F, Sousa J. ...
  • ۵.Abbaspour MR, Sadeghi F, Afrasiabi Garekani H. Thermal treating as ...
  • ۶.Zelko R, Orban A, Suvegh K, Riedl Z, Racz I. ...
  • ۷.Wang CC, Zhang G,Shah NH, Infeld MH, Malick AW, McGinity ...
  • ۸.Zhu Y, Shah NH, Malick AW, Infeld MH, McGinity JW. ...
  • ۹.Costa Fo, Sousa JJS, Pais AACC, Formosinho SJ. Comparison of ...
  • ۱۰.Dukic-Ott A, Thommes M, Remon JP, Kleinebudde P, Vervaet C. ...
  • ۱۱.Lustig C, Kaur H, Podczeck F, Newton JM. The influence ...
  • ۱۲.Felton LA, McGinity W. Influence of plasticizers on the adhesive ...
  • ۱۳.Fujimori J, Yoshihashi Y, Yonemochi E, Terada K. Application of ...
  • ۱۴.Fielden KE, Newton JM, Rowe RC. The influence of moisture ...
  • ۱۵.Sadeghi F, Afrasiabi Garekani H, Goli F. Tableting of Eudragit ...
  • ۱۶.Sadeghi F, Afrasiabi Garekani H, Sadr A. Influence of polymer ...

Research Info Management

Certificate | Report | من نویسنده این مقاله هستم

اطلاعات استنادی این Paper را به نرم افزارهای مدیریت اطلاعات علمی و استنادی ارسال نمایید و در تحقیقات خود از آن استفاده نمایید.

Scientometrics

The specifications of the publisher center of this Paper are as follows:
Type of center: علوم پزشکی
Paper count: 8,363
In the scientometrics section of CIVILICA, you can see the scientific ranking of the Iranian academic and research centers based on the statistics of indexed articles.

Share this page

More information about COI

COI stands for "CIVILICA Object Identifier". COI is the unique code assigned to articles of Iranian conferences and journals when indexing on the CIVILICA citation database.

The COI is the national code of documents indexed in CIVILICA and is a unique and permanent code. it can always be cited and tracked and assumed as registration confirmation ID.

Support