Anti-inflammatory, Antipruritic and Mast Cell Stabilizing Activity of Aristolochia Indica

Objective(s) Aristolochia indica has been widely used in the traditional medicine for the treatment of a variety of diseases. In the present study different extracts of roots of A. indica were evaluated for their anti inflammatory, antipruritic and mast cell stabilizing activity. Materials and Methods Anti-inflammatory activity was performed by compound ۴۸/۸۰ induced rat paw edema model and antipruritic activity by examining the incidence of scratching behavior. Mast cell stabilizing activity was performed by compound ۴۸/۸۰ and sheep serum induced mast cell degranulation methods. Results The ethanol extract (۳۰۰ mg/kg) and petroleum ether extract (۱۰۰ mg/kg) were found to inhibit mast cell degranulation significantly equivalent to that of standard drug ketotifen (۶۹%) by compound ۴۸/۸۰ model. In sheep serum model the ethanol extracts (۱۵۰ and ۳۰۰ mg/kg) and petroleum ether extract (۱۰۰ mg/kg) showed good mast cell stabilizing activity (۶۶-۶۷%). Ethanol extract at ۱۵۰ mg/kg showed ۷۰% reduction of rat paw oedema and also significantly reduced the scratching response. Conclusion Results suggest A. indica has good mast cell stabilizing, anti-inflammatory and antipruritic activity.

Keywords:

Anti-inflammatory , Anti-antipruritic , Aristolochia indica , Mast cell stabilizing activity