Protective Effect of Urtica dioica L. (Urticaceae) on Morphometric and Morphologic Alterations of Seminiferous Tubules in STZ Diabetic Rats
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 14، Issue: 5
Publish Year: 1390
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-14-5_010
تاریخ نمایه سازی: 3 آبان 1400
Abstract:
Objective(s) Urtica dioica L. has been known as a medicinal plant in the world. This study was conducted to determine the effects of the hydroalcoholic extract of Urtica dioica leaves on seminiferous tubules of diabetic rats. Materials and Methods Animals were allocated to control, diabetic and protective groups. Treated animals received extract of U. dioica (۱۰۰ mg/ kg/ day) IP for the first ۵ days and STZ injection on the ۶th day. After ۵ weeks, testes removed and stained with H&E technique. Results Tubular cell disintegration, sertoli and spermatogonia cell vacuolization, and decrease in sperm concentration observed in diabetic in comparison with control and protective groups. External seminiferous tubular diameter and seminiferous epithelial height significantly reduced (P< ۰.۰۵) in diabetic compared with controls, and these parameters increased (P< ۰.۰۵) in the treated compared with diabetics. Conclusion Hydroalcoholic extract of U. dioica, before induction of diabetes; has protective role on seminiferous tubules alterations.
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Authors
Mohammad Jafar Golalipour
Department of Anatomy (Embryology and Histology), Golestan University of Medical Sciences, Gorgan, Iran
Babak Kabiri Balajadeh
Department of Anatomy (Embryology and Histology), Golestan University of Medical Sciences, Gorgan, Iran
Soraya Ghafari
Department of Anatomy (Embryology and Histology), Golestan University of Medical Sciences, Gorgan, Iran
Ramin Azarhosh
Department of Pathology, Golestan University of Medical Sciences, Gorgan, Iran
Vahid Khori
Department of Pharmacology, Golestan University of Medical Sciences, Gorgan, Iran
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