CIVILICA We Respect the Science
(ناشر تخصصی کنفرانسهای کشور / شماره مجوز انتشارات از وزارت فرهنگ و ارشاد اسلامی: ۸۹۷۱)

Preventive and Therapeutic Vaccines against Human Papillomaviruses Associated Cervical Cancers

عنوان مقاله: Preventive and Therapeutic Vaccines against Human Papillomaviruses Associated Cervical Cancers
شناسه ملی مقاله: JR_IJBMS-15-1_001
منتشر شده در در سال 1391
مشخصات نویسندگان مقاله:

Nayereh Khadem Ghaebi - Women’s Health Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran
Zahra Meshkat - Microbiology and Virology Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran

خلاصه مقاله:
Cervical cancer is, globally known to be, one of the most common cancers among women especially indeveloping countries. More than ۹۰% of cervical cancers are associated with high-risk humanpapillomaviruses (HPVs) particularly HPV types ۱۶ and ۱۸. Two major strategies have been developed forprevention and treatment of cervical cancer and other HPV-associated malignancies; the first one is based onHPV virus-like particles (VLPs) containing HPV structural proteins. VLP based vaccines can inducegenotype specific virus neutralizing antibodies for preventing HPV infections. The other strategy is based onHPV early genes especially E۶ and E۷ for eliminating the established HPV infections; therefore they areclassified as HPV therapeutic vaccines. This article reviews the preventive and therapeutic vaccines againstHPV infections and cervical cancer.

کلمات کلیدی:
Cervical Cancer, Human papillomavirus, Preventive vaccine, Therapeutic vaccine

صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1297059/