The anti-inflammatory effects of venlafaxine in the rat model of carrageenan-induced paw edema

Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJBMS-18-7_005

تاریخ نمایه سازی: 3 آبان 1400

Abstract:

Objective(s):Recently anti-inflammatory effects of antidepressants have been demonstrated. Venlafaxine belongs to newer antidepressants with serotonin norepinephrine reuptake inhibition property. The pain alleviating properties of venlafaxine in different pain models such as neurogenic pain, diabetic neuropathy, and fibromyalgia have been demonstrated. Anti-inflammatory effects of venlafaxine and also its underlying mechanisms remain unclear. The present study was designed to evaluate the anti-inflammatory effects of venlafaxine and determine possible underlying mechanisms. Materials and Methods: We examined the anti-inflammatory effects of intraperitoneal (IP) and intracerebroventricular (ICV) administration of venlafaxine in the rat model of carrageenan-induced paw edema. Results: Our results showed that both IP (۵۰ and ۱۰۰ mg/kg) and ICV (۵۰ and ۱۰۰ μg/rat) injection of venlafaxine inhibited carrageenan-induced paw edema. Also IP and ICV administration of venlafaxine significantly decreased myeloperoxidase (MPO) activity and interleukin (IL)-۱β and tumor necrosis factor (TNF)-α production. Finally, we tried to reverse the anti-inflammatory effect of venlafaxine by yohimbine (۵ mg/kg, IP), an alpha۲-adrenergic antagonist. Our results showed that applied antagonist failed to change the anti-inflammatory effect of venlafaxine. Conclusion: These results demonstrated that venlafaxine has potent anti-inflammatory effect which is related to the peripheral and central effects of this drug. Also we have shown that anti-inflammatory effect of venlafaxine is mediated mostly through the inhibition of IL-۱β and TNF-α production and decreases MPO activity in the site of inflammation.

Authors

Valiollah Hajhashemi

Department of Pharmacology and Toxicology and Isfahan Pharmaceutical Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Mohsen Minaiyan

Department of Pharmacology and Toxicology and Isfahan

Hamid Reza Banafshe

Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran

Azam Mesdaghinia

Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran

Alireza Abed

Department of Pharmacology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran

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  • Bohren Y, Tessier LH, Megat S, Petitjean H, Hugel S, ...
  • Kostadinov ID, Delev DP, Murdjeva MA, Kostadinova II. Experimental study ...
  • Saito H, Wakai J, Sekiguchi M, Kikuchi S, Konno S. ...
  • Hochstrasser T, Ehrlich D, Sperner-Unterweger B, Humpel C. Antidepressants and ...
  • Baldessarini R J. Drugs for the treatment of psychiatric disorders. ...
  • Sumpton JE, Moulin DE. Treatment of neuropathic pain with venlafaxine. ...
  • Cegielska-Perun K, Bujalska-Zadrożny M, Tatarkiewicz J, Gąsińska E, Elżbieta H, ...
  • Dwight MM, Arnold LM, O’Brien H, Metzger R, Morris-Park E, ...
  • Ellingrod VL, Perry PJ.Venlafaxine: a heterocyclic antidepressant. Am J Hosp ...
  • Budantsev AI, Kisliuk OS, Shul'govskii VV, Rykunov DS, Iarkov AV. ...
  • Winter CA, Risely EA, Nuss GW. Carrageenin-induced edema in hind ...
  • Aricioğlu F, Buldanlioğlu U, Salanturoğlu G, Ozyalçin NS. Evaluation of ...
  • Hajhashemi V, Banafshe HR, Minaiyan M, Mesdaghinia A, Abed A. ...
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  • Gilligan JP, Lovato SJ, Erion MD, Jeng AY. Modulation of ...
  • Halici Z, Dengiz GO, Odabasoglu F, Suleyman H, Cadirci E, ...
  • Nacife VP, Soeiro MN, Gomes RN, D'Avila H, Castro-FariaNeto HC, ...
  • Codarri L, Fontana A, Becher B. Cytokine networks in multiple ...
  • Feldmann M, Maini SR. Role of cytokines in rheumatoid arthritis: ...
  • Ichinose M, Barnes PJ. Cytokine-directed therapy in asthma. Curr Drug ...
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  • Kovaru H, Pav M, Kovaru F, Raboch J, Fiserova A. ...
  • Tian L, Rauvala H, Gahmberg CG. Neuronal regulation of immune ...
  • Eskandari F, Webster JI, Sternberg EM. Neural immune pathways and ...
  • Berrocoso E, Mico JA. In vivo effect of venlafaxine on ...
  • Egan TM, Henderson G, North RA, Williams JT. Noradrenaline-mediated synaptic ...
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