Hawthorn ethanolic extracts with triterpenoids and flavonoids exert hepatoprotective effects and suppress the hypercholesterolemia-induced oxidative stress in rats

Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
View: 84

This Paper With 9 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_IJBMS-18-7_011

تاریخ نمایه سازی: 3 آبان 1400

Abstract:

Objective(s):The current study was aimed to determine the bioactive constituents and biological effects of the Crataegus monogyna ethanolic extracts from bark, leaves and berries on hypercholesterolemia. Materials and Methods: Oleanolic acid, ursolic acid, quercetin and lupeol concentrations were quantified by HPLC. Total phenol content and radical scavenging activity of extracts were also measured. The hypocholesterolemic, antioxidant, and hepatoprotective effects of the extracts were examined in hypercholesterolemic rats and compared with orlistat. Results: The highest phenol content, oleanolic acid, quercetin and lupeol levels and free radical scavenging potency were found in the bark extract, and the highest ursolic acid level was found in the berries extract. Orlistat and extracts significantly (P<۰.۰۵) lowered the hypercholesterolemia-increased serum level of hepatic enzymes and lipid peroxidation level. Hawthorn’s extracts protected from hepatic thiol depletion and improved the lipid profile and hepatic damages. Conclusion: Data suggested that hawthorn’s extracts are able to protect from hypercholesterolemia-induced oxidative stress and hepatic injuries. Moreover, the hypocholesterolemic effect of extracts was found comparable to orlistat.

Authors

Ali Rezaei-Golmisheh

Department of Histology and Embryology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Hassan Malekinejad

Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Siamak Asri-Rezaei

Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Amir Abbas Farshid

Department of Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Peyman Akbari

Division of Veterinary Pharmacy, Pharmacology and Toxicology, Faculty of Science, Utrecht University, The Netherlands

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
  • Petkov V. Plants with hypotensive, antiathero-matous and coronarodilatating action. Am ...
  • Rigelsky JM, Sweet BV. Hawthorn: pharmacology and therapeutic uses. Am ...
  • Tassell MC, Kingston R, Gilroy D, Lehane M, Furey A. ...
  • Rajendran S, Deepalakshmi P, Parasakthy K, Devaraj H, Devaraj SN. ...
  • Lin Y, Vermeer MA, Trautwein EA. Triterpenic acids present in ...
  • Zhang Z, Chang Q, Zhu M, Huang Y, Ho WK, ...
  • Liu P, Yang B, Kallio H. Characterization of phenolic compounds ...
  • D'Mello PM, Joshi UJ, Shetgiri PP, Dasgupta TK, Darji KK. ...
  • Saboo S, Taapadiya G, Khadabadi S. Antioxidant and hepatoprotective potential ...
  • Singleton VL, Orthofer R, Lamuela-Raventos RM. Analysis of total phenols ...
  • Mensor LL, Menezes FS, Leitão GG, Reis AS, Santos TCd, ...
  • Lu LS, Wu CC, Hung LM, Chiang MT, Lin CT, ...
  • Hosseinimehr SJ, Azadbakht M, Abadi AJ. Protective effect of hawthorn ...
  • Caner M, Dogruman H, Taskin E, Kandil A, Demirci C. ...
  • Ranjbar A, Khorami S, Safarabadi M, Shahmoradi A, Malekirad AA, ...
  • Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement ...
  • Niehaus W, Samuelsson B. Formation of malonaldehyde from phospholipid arachidonate ...
  • Wang H, Zhang Z, Guo Y, Sun P, Lv X, ...
  • Kwok CY, Wong CNY, Yau MYC, Yu PHF, Au ALS, ...
  • Kushner R. Medical management of obesity. Semin Gastrointest Dis ۲۰۰۲; ...
  • Baskar R, Meenalakshmi Malini M, Varalakshmi P, Balakrishna K, Bhima ...
  • Saratha V, Subramanian SP. Lupeol, a triterpenoid isolated from Calotropis ...
  • Nagaraj M, Sunitha S, Varalakshmi P. Effect of lupeol, a ...
  • Saleem M, Afaq F, Adhami VM, Mukhtar H. Lupeol modulates ...
  • Saleem M, Kaur S, Kweon M-H, Adhami VM, Afaq F, ...
  • Sudhahar V, Kumar SA, Varalakshmi P. Role of lupeol and ...
  • Itoh M, Hiwatashi K, Abe Y, Kimura F, Toshima G, ...
  • Radhiga T, Rajamanickam C, Senthil S, Pugalendi KV. Effect of ...
  • Azevedo MF, Camsari Ç, Sá CM, Lima CF, Fernandes Ferreira ...
  • Jeong W, Jeong D-H, Do S-H, Kim Y-K, Park H-Y, ...
  • Beltroy EP, Liu B, Dietschy JM, Turley SD. Lysosomal unesterified ...
  • Wang D, Wei Y, Pagliassotti MJ. Saturated fatty acids promote ...
  • Abo Salem OM, Abd Ellah MF, Ghonaim MM. Hepatoprotective activity ...
  • Domitrović R, Jakovac H, Vasiljev Marchesi V, Vladimir-Knežević S, Cvijanović ...
  • نمایش کامل مراجع