Effects of silymarin on neuropathic pain and formalin-induced nociception in mice

Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJBMS-18-7_015

تاریخ نمایه سازی: 3 آبان 1400

Abstract:

Objective(s):Based on the previous reports, silymarin can suppress nitric oxide, prostaglandin E۲ (PGE۲), leukotrienes, cytokines production, and neutrophils infiltration. Regarding the fact that inflammation plays an important role in neuropathic and formalin-induced pain, it was assumed that silymarin could reduce pain. The present study investigates the analgesic effects of silymarin in chemical nociception and a model of neuropathic pain. Materials and Methods: Chemical nociception was produced by injection of ۲۰ µl of formalin (۰.۵% formaldehyde in saline) into the plantar region of the right hind paw. A sciatic-nerve ligated mouse was applied as the model of neuropathic pain and the antinociceptive response of silymarin was examined ۱۴ days after unilateral nerve-ligation using the hot plate test. Results:The intraperitoneal administration of silymarin (۲۵, ۵۰, and, ۱۰۰ mg/kg) ۲ hr prior to the intraplantar formalin injection suppressed the nociceptive response during the late phase of the formalin test significantly, but it was not in a dose-dependent manner. Different doses of silymarin ۱۴ days after unilateral sciatic nerve ligation in hot plate test did not induce obvious antinociception. Conclusion:Results of the present study indicated that repeated administration of silymarin prevents the formalin-induced nociceptive behavior. However, it is not effective in the treatment of sciatic neuropathic pain.

Authors

Faezeh Vahdati Hassani

School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Ramin Rezaee

Department of Physiology and Pharmacology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran

Hasan Sazegara

School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Mahmoud Hashemzaei

Department of Pharmacology and Toxicology, School of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran

Kobra Shirani

School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Gholamreza Karimi

Medical Toxicology Research Center and Pharmacy School, Mashhad University of Medical Sciences, Mashhad, Iran

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