Leila Azimi - Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Ali Pourmotabbed - Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Mohammad Rasool Ghadami - Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Seyed Ershad Nedaei - Department of Neuroscience, School of Advanced Medical Technologies, Tehran University of Medical Sciences, Tehran, Iran
Targol Pourmotabbed - Student of Information Technology, Kermanshah University of Technology, Kermanshah, Iran

Objective(s) Cyclooxygenases  (COXs) are known to play some roles in physiological mechanisms related to learning and memory. Since sodium salicylate is an inhibitor of COX, we have evaluated the effect of peripheral and intra-hippocampal administration of sodium salicylate on spatial learning and memory in male rats. Materials and Methods Male rats were studied in two groups; the first group received different intraperitoneal (i.p.) sodium salicylate doses (۰, ۲۰۰, ۳۰۰, and ۴۰۰ mg/kg) and the second group received intra-hippocampal doses of the drug (۰, ۳۰, ۵۰, and ۱۰۰ μg/۰.۵ μl/side). The spatial performance of rats was tested using Morris water maze (MWM) task. The spatial learning and memory parameters were analyzed using ANOVA. Results Peripheral and intra-hippocampal administration of sodium salicylate did not lead to a statistically significant change in the mean time (escape latency), and also the distance traveled for finding the hidden platform during the training days, compared with the control group. But at the probe trial, the percentage of time spent in the target quadrant by rats which received the highest doses of drug significantly increased. Conclusion We found that both peripheral and intra-hippocampal administration of sodium salicylate facilitates the process of spatial memory consolidation in the MWM.

Cyclooxygenase, Rat, Sodium salicylate, Spatial Memory