Folic Acid and Coenzyme Q۱۰ Ameliorate Cognitive Dysfunction in the Rats with Intracerebroventricular Injection of Streptozotocin

Publish Year: 1391
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJBMS-15-2_005

تاریخ نمایه سازی: 3 آبان 1400

Abstract:

Objective(s) The present study aimed to investigate the effects of a fat soluble antioxidant, coenzyme Q۱۰ (CoQ۱۰) and folic acid on learning and memory in the rats with intracerebroventricular injection of streptozotocin (ICV-STZ), an animal model of sporadic type of Alzheimer's disease. Materials and Methods The lesion groups were injected bilaterally with ICV-STZ (۱.۵ mg/kg b.wt., in normal saline). In the treated groups, rats received folic acid (۴ mg/kg; i.p.) or CoQ۱۰ (۱۰ mg/kg; i.p.), either alone or together, for ۲۱ days. Passive avoidance learning test was used for evaluation of learning and memory. Results The results showed that learning and memory performance was significantly impaired in the rats with ICV-STZ (P< ۰.۰۰۱), however CoQ۱۰ and folic acid, either alone or together, prevented impairments significantly (P< ۰.۰۰۱), as there was not any significant difference between these treated lesion groups and control group. Conclusion The present results suggest that CoQ۱۰ and folic acid have therapeutic and preventive effects on cognitive impairments in Alzheimer’s disease.  

Authors

Hamid Reza Dehghani Dolatabadi

Department of Basic Sciences, Isfahan Payame Noor University, Isfahan, Iran

Parham Reisi

Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Hojjatallah Alaei

Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Hamid Azizi Malekabadi

Department of Basic Sciences, Islamic Azad University Khorasgan Branch, Isfahan, Iran

Ali Asghar Pilehvarian

Department of Basic Sciences, Isfahan Payame Noor University, Isfahan, Iran

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