Hamid Reza Dehghani Dolatabadi - Department of Basic Sciences, Isfahan Payame Noor University, Isfahan, Iran
Parham Reisi - Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Hojjatallah Alaei - Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Hamid Azizi Malekabadi - Department of Basic Sciences, Islamic Azad University Khorasgan Branch, Isfahan, Iran
Ali Asghar Pilehvarian - Department of Basic Sciences, Isfahan Payame Noor University, Isfahan, Iran

Objective(s) The present study aimed to investigate the effects of a fat soluble antioxidant, coenzyme Q۱۰ (CoQ۱۰) and folic acid on learning and memory in the rats with intracerebroventricular injection of streptozotocin (ICV-STZ), an animal model of sporadic type of Alzheimer's disease. Materials and Methods The lesion groups were injected bilaterally with ICV-STZ (۱.۵ mg/kg b.wt., in normal saline). In the treated groups, rats received folic acid (۴ mg/kg; i.p.) or CoQ۱۰ (۱۰ mg/kg; i.p.), either alone or together, for ۲۱ days. Passive avoidance learning test was used for evaluation of learning and memory. Results The results showed that learning and memory performance was significantly impaired in the rats with ICV-STZ (P< ۰.۰۰۱), however CoQ۱۰ and folic acid, either alone or together, prevented impairments significantly (P< ۰.۰۰۱), as there was not any significant difference between these treated lesion groups and control group. Conclusion The present results suggest that CoQ۱۰ and folic acid have therapeutic and preventive effects on cognitive impairments in Alzheimer’s disease.  

Alzheimer disease, Coenzyme Q۱۰, folic acid, Passive avoidance learning, Streptozotocin