Inhibitory Activity of Eleven Artemisia Species from Iran against Leishmania Major Parasites
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 15، Issue: 2
Publish Year: 1391
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-15-2_014
تاریخ نمایه سازی: 3 آبان 1400
Abstract:
Objective(s) Annual incidence of cutaneous leishmaniasis is increasingly growing and development of the alternative drugs against it is a major concern. Artemisia genus is a traditional medicinal plant in Iran. The aim of this study was to examine the leishmanicidal activity of various Iranian Artemisia species extracts. Materials and Methods Different extracts were gathered from eleven Iranian Artemisia species. Their leishmanicidal activities against the growth of Leishmania major (L. major)promastigotes were examined as the half maximal inhibitory concentration(IC۵۰) using MTT assay. Results Obtained results showed that ethanol extracts especially those taken from A. ciniformis, A. santolina and A. kulbadica have the strongest effects. Conclusion Looking for the effective leishmanicidal agents from natural resources in Iran, we found that the ethanol extract of collected Artemisia species had significant effect on in vitro leishmanicidal activity and may be suitable candidates in the treatment of leishmaniasis.
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Authors
Seyed Ahmad Emami
Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Shahrzad Zamanai Taghizadeh Rabe
Immunology Research Centre, BuAli Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran
Ali Ahi
Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Mahmoud Mahmoudi
Immunology Research Centre, BuAli Research Institute, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
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