Oytun Erbas - Gaziosmanpasa University Faculty of Medicine, Department of Physiology, Tokat Turkey
Huseyin Anil Korkmaz - Izmir Dr Behcet Uz Pediatric Medicine and Surgery Training and Research Hospital, Pediatric Endocrinology Clinic, Izmir, Turkey
Fatih Oltulu - Ege University School of Medicine, Department of Histology and Embryology, Izmir, Turkey
Hüseyin Aktug - Ege University School of Medicine, Department of Histology and Embryology, Izmir, Turkey
Altug Yavasoglu - Ege University School of Medicine, Department of Histology and Embryology, Izmir, Turkey
Levent Akman - Ege University School of Medicine, Department of Gynecology and Obstetrics, Izmir, Turkey
Volkan Solmaz - Gaziosmanpasa University Faculty of Medicine, Department of Neurology, Tokat, Turkey
Dilek Taskiran - Ege University Faculty of Medicine, Department of Physiology, Izmir, Turkey

Objective(s):The purpose of the present study was to investigate the protective effect of oxytocin on cisplatin (CP)-induced renal damage in rats. Materials and Methods: Fourteen adult Sprague Dawley rats, weighing ۲۰۰ to ۲۱۰, were administered by cisplatin (CP, ۲ mg/kg/day) twice a week for five weeks. Then, they were randomly divided into two groups and treated with either saline (۱ ml/kg/day) or OT                       (۲۰۰ µg/kg/day) for five weeks. Seven rats served as control group. At the end of the treatment period, animals were sacrificed and their kidneys were assessed histologically. In addition,            C-reactive protein (CRP), TGF-β and Akt expression were evaluated immunohistochemically. Results:Both tubules and glomeruli were found to be severely damaged with marked medullary tubulo-interstitial inflammation due to chronic cisplatin exposure, particularly in the saline-treated group (Group ۱) compared to control group. Oxytocin treatment spared renal tissue significantly by suppressing CRP and TGF-β, and enhancing Akt expression. Conclusion: We conclude that renal damage due to cisplatin toxicity was prevented to a great extent by the anti-inflammatory effect of oxytocin.   

Akt, Cisplatin toxicity, CRP, Kidney, Oxytocin TGF-β