Gabapentin enhances anti-nociceptive effects of morphine on heat, cold, and mechanical hyperalgesia in a rat model of neuropathic pain

Publish Year: 1393
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJBMS-17-10_005

تاریخ نمایه سازی: 4 آبان 1400

Abstract:

Objective(s):Neuropathic pain is caused by lesions or diseases affecting the somatosensory system and often responds poorly to typical medications.  In this study, we evaluated anti-nociceptive effects of morphine, gabapentin and their combination on heat hyperalgesia, cold and mechanical allodynia in chronic constriction injury (CCI) model of neuropathic pain in rats. Materials and Methods: Morphine (۲, ۴ and ۸ mg/kg) and gabapentin (۵, ۱۰ and ۲۰ mg/kg) were administered either alone or in combination (morphine ۲ mg/kg and gabapentin ۵ mg/kg). Results:Our results showed that morphine and gabapentin alone produce anti-nociceptive effects at higher doses (morphine ۴ and ۸ mg/kg and gabapentin ۱۰ and ۲۰ mg/kg) whereas their combination resulted in better analgesia at lower doses as compared to other treatment groups (morphine ۲ mg/kg or gabapentin ۵ mg/kg). Conclusion: These findings suggest that gabapentin potentiates the analgesic effects of morphine in the chronic constriction injury (CCI) model of neuropathic pain and combination of these drugs may be considered as a beneficial treatment for neuropathic pain.

Authors

Gholam Ali Hamidi

Physiology Research Center, Kashan University of Medical Sciences, Kashan. Iran

Majid Jafari-Sabet

Department of Pharmacology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran

Alireza Abed

Department of Pharmacology, School of Medicine, Kashan University of Medical Sciences, Kashan. Iran ۵ Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan,

Azam Mesdaghinia

Physiology Research Center, Kashan University of Medical Sciences, Kashan. Iran .Department of Pharmacology, School of Medicine, Kashan University of Medical Sciences, Kashan. Iran

Mohadeseh Mahlooji

Physiology Research Center, Kashan University of Medical Sciences, Kashan. Iran .Department of Pharmacology, School of Medicine, Kashan University of Medical Sciences, Kashan. Iran

Hamid Reza Banafshe

Department of Addiction Studies, School of Medicine, Kashan University of Medical Sciences, Kashan. Iran Physiology Research Center, Kashan University of Medical Sciences, Kashan. Iran

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