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Antidiabetic and hypolipidemic effects of Dorema aucheri hydroalcoholic leave extract in streptozotocin-nicotinamide induced type ۲ diabetes in male rats

Publish place: Iranian Journal of Basic Medical Sciences، Vol: 17، Issue: 10
Publish Year: 1393
نوع سند: مقاله ژورنالی
زبان: English
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https://civilica.com/doc/1297769

شناسه ملی سند علمی:

JR_IJBMS-17-10_014

تاریخ نمایه سازی: 4 آبان 1400

Abstract:

Objective(s):The present study investigated the antidiabetic and hypolipidemic properties of Dorema aucheri leave hydroalcoholic extract in nicotinamide-streptozotocin induced type ۲ diabetic rats. Materials and Methods: nicotinamide/streptozotocin-induced diabetic rats were supplemented orally with three different doses of D.  aucheri (۱۰۰, ۲۰۰ and ۴۰۰ mg/kg BW) or glibenclamide (۰.۲۵ mg/kg) for ۴ weeks. Ultimately, blood of animals has taken and glucose, insulin, lipid profiles, SGPT, alkaline phosphatase, SGOT, leptin levels were assayed. Results: D. aucheri has highly significant blood glucose lowering effect. Administration of the extract to diabetic rats resulted in a remarkable change in serum lipid profiles, insulin and leptin levels relative to diabetic group. Also the extract reversed back the serum levels of SGPT, alkaline phosphatase and SGOT to near normal in treated diabetic rats. Conclusion: D. aucheri could be useful in treatment of diabetes. Moderate dose of D. aucheri (۲۰۰ mg/kg) was more effective than the others.

Keywords:

Diabetes , Dorema aucheri , Insulin , Nicotinamide , Streptozotocin

Authors

Akram Ahangarpour

Health Research institute, Diabetes Research Center, Dept of Physiology, Faculty of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Hossein Teymuri Zamaneh

Faculty of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Ayob Jabari

Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran

Hamid Malekshahi Nia

Department of sport physiology, Faculty of physical education and sport science, Shahid Chamran University of Ahvaz, Ahvaz, Iran

Hamid Heidari

Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences. Ahvaz, Iran and Department of Physiology, Faculty of Medical Sciences, Qom University of Medical Sciences, Qom, Iran

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