Preventive Effect of Novel Bacterial Polysaccharide and Animal Splenic Protein as Natural Adjuvants on Animal Model of Asthma

Publish Year: 1391
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJBMS-15-5_010

تاریخ نمایه سازی: 4 آبان 1400

Abstract:

Objective(s) Two new adjuvants from natural animal lipids (G۲) and bacterial polysaccharide extracts (PC) were previously prepared by our group and showed a reduction in tracheal responsiveness. The aim of this study was to evaluate the preventive effect of recently introduced natural products (G۲ and PC) on the development of asthma. Materials and Methods Asthma was induced using a standard method in four groups of BALB/c mice. A non-sensitized control group was also included in order to be compared with treated groups. Three groups were premedicated           with novel agents named G۲, PC, and a combination of these two for ۲۰ days before starting  the induction of asthma. Bronchoalveolar lavage fluid (BALF) was collected and analyzed for inflammatory cells.  Interferon-γ, and IL-۴ and the histopathological of both lungs were also evaluated. Results In all pretreated groups, the inflammatory cells infiltration especially eosinophils and smooth muscle hyperplasia decreased significantly. BALF cytology also showed significant decrease in eosinophil              count in all pretreated groups. There was a significant increase in the BALF and serum INF-γ in all pretreated groups but the combination of G۲/PC was more effective. BALF IL-۴ decreased significantly in                                 the group pretreated with a combination of G۲ and G۲/PC (۴.۱۱±۰.۸۶ and ۴.۰۲±۰.۵۲ pg/ml in G۲ and G۲/PC, respectively). Serum IL-۴ in the PC group was significantly higher than the sensitized control. Conclusion G۲ and PC may effectively prevent asthma development by activation of the type ۱ T helper system.  

Authors

Majid Mirsadraee

Department of Internal Medicine, Medical School of Islamic Azad University- Mashhad Branch, Mashhad, Iran

Saleh Mohaghegh Hazrati

Mohaghagh Hazreati Immunology and Biotechnology Researches Centre, Tehran Iran

Mohammad Reza Khakzad

Department of Immunology, Medical School of Islamic Azad University, Mashhad Branch, Mashhad, Iran

Kamran Ghafarzadegan

Department of Pathology Razavi Hospital, Mashhad, Iran

Mohhamad Hosein Boskabady

Mashhad University of Medical Science, Mashhad, Iran

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