The Effects of Cyclooxygenase Inhibitors on the Brain Inflammatory Response Following Traumatic Brain Injury in Rats

Objective(s) Cytokines such as IL-۱β are involved in inflammatory responses. This study evaluated the role of two different kinds of drugs (ibuprofen and celecoxib) on brain IL-۱۰ and IL-۱β after traumatic brain injury (TBI) in male rats. Materials and Methods Rats were assigned into ۶ groups: intact, sham, TBI, and treated rats with vehicle, celecoxib or iboprophen. Cytokine concentrations were quantified by ELISA kits. Results Groups showed no significant difference in brain IL-۱۰ either after TBI induction or after treatment with ibuprofen or celecoxib. Serum IL-۱۰ in vehicle or ibuprofen treated animals was lower than in sham groups (P< ۰.۰۱). Brain IL-۱β decreased after treatment by ibuprofen or celecoxib (P< ۰.۰۰۱). There was no statistical difference in serum IL-۱β in TBI and intact. Serum IL-۱β significantly decreased in rats that received celecoxib compared to TBI group (P< ۰.۰۱). Conclusion Based on our study IL-۱β can decrease through both cyclooxygenase ۱ (COX-۱) and COX-۲ pathway but serum IL-۱β can decrease only by COX-۲ pathway.

Keywords:

Brain injury , Celecoxib , Ibuprofen , Interleukin-۱۰