AM۲۸۱, Cannabinoid Antagonist/Inverse agonist, Ameliorates Scopolamine-Induced Cognitive Deficit
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 15، Issue: 5
Publish Year: 1391
نوع سند: مقاله ژورنالی
زبان: English
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JR_IJBMS-15-5_016
تاریخ نمایه سازی: 4 آبان 1400
Abstract:
Objective(s) Cannabinoids have been implicated in memory deficit. We examined the effect of AM۲۸۱, cannabinoid antagonist/inverse agonist in prevention of scopolamine-induced cognitive deficit. Materials and Methods Object recognition task was used to evaluate memory in mice. Exploration time in the first and the second trial was recorded. The differences in exploration between a previously seen object and a novel object in second trial were taken as an index of memory. Scopolamine and AM۲۸۱ were administrated at the same time, ۴۰ min before second trial in the treatment group. Results Object discrimination was impaired after scopolamine (۲ mg/kg; IP) administration. AM۲۸۱ (۲.۵, ۵ mg/kg; IP) significantly restored object recognition ability in mice treated with scopolamine by ۷۵%. Conclusion This study extends earlier findings, suggesting the interaction of cannabinoid and cholinergic system in memory. Additionally cannabinoid antagonists seem to show variable pharmacological properties.
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Authors
Mohammed Rabbani
Department of Pharmacology, Isfahan Pharmaceutical Sciences Research Centre, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
Golnaz Vaseghi
Department of Pharmacology, Isfahan Pharmaceutical Sciences Research Centre, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
Valiollah Hajhashemi
Department of Pharmacology, Isfahan Pharmaceutical Sciences Research Centre, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
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