Urine Monocyte Chemoattractant Protein-۱(UMCP-۱) as a Biomarker of Renal Involvement in Systemic Lupus Erythematosus
عنوان مقاله: Urine Monocyte Chemoattractant Protein-۱(UMCP-۱) as a Biomarker of Renal Involvement in Systemic Lupus Erythematosus
شناسه ملی مقاله: JR_IJBMS-15-6_012
منتشر شده در در سال 1391
شناسه ملی مقاله: JR_IJBMS-15-6_012
منتشر شده در در سال 1391
مشخصات نویسندگان مقاله:
Zahra Mirfeizi - Rheumatic Diseases Research Centre (RDRC), Mashhad University of Medical Sciences, Mashhad, Iran
Mahmoud Mahmoudi - Immunology Research Centre (IRC), Mashhad University of Medical Sciences, Mashhad, Iran
Masih Naghibi - Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammmadreza Hatef - Rheumatic Diseases Research Centre (RDRC), Mashhad University of Medical Sciences, Mashhad, Iran
Farzaneh Sharifipour - Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammadhassan Jokar - Rheumatic Diseases Research Centre (RDRC), Mashhad University of Medical Sciences, Mashhad, Iran
Abbasali Zeraati - Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Zhaleh Shariati Sarabi - Rheumatic Diseases Research Centre (RDRC), Mashhad University of Medical Sciences, Mashhad, Iran
AmirAbbas Azarian - Vice Chancellor for Research Office, Mashhad University of Medical Sciences, Mashhad, Iran
خلاصه مقاله:
Zahra Mirfeizi - Rheumatic Diseases Research Centre (RDRC), Mashhad University of Medical Sciences, Mashhad, Iran
Mahmoud Mahmoudi - Immunology Research Centre (IRC), Mashhad University of Medical Sciences, Mashhad, Iran
Masih Naghibi - Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammmadreza Hatef - Rheumatic Diseases Research Centre (RDRC), Mashhad University of Medical Sciences, Mashhad, Iran
Farzaneh Sharifipour - Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammadhassan Jokar - Rheumatic Diseases Research Centre (RDRC), Mashhad University of Medical Sciences, Mashhad, Iran
Abbasali Zeraati - Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Zhaleh Shariati Sarabi - Rheumatic Diseases Research Centre (RDRC), Mashhad University of Medical Sciences, Mashhad, Iran
AmirAbbas Azarian - Vice Chancellor for Research Office, Mashhad University of Medical Sciences, Mashhad, Iran
Objective(s)Lupus nephritis (LN) is frequently associated with a poor long-term prognosis. Renal biopsy is the diagnostic method of choice in this condition. Urine biomarkers have been mentioned in the diagnosis of LN. The study,s purpose was to evaluate the performance of urinary monocyte chemoattractant protein ۱(UMCP-۱) as a biomarker of renal involvement in systemic lupus erythematosus.Materials and MethodsForty-one recently diagnosed systemic lupus erythematosus patients (۸ male and ۳۳ female) without renal involvement (group ۱) and twenty six patients (۸ male and ۱۸ female) with LN (group ۲), proven by biopsy, were recruited to this study. UMCP-۱ sensitivity and specificity for identifying biopsy-proven nephritis were calculated, and a receiver operating characteristic (ROC) curve was constructed to quantify how definitely UMCP-۱ distinguishes between patients with and without LN.ResultsThe mean value of UMCP-۱ levels were ۷۳۳.۰۷ pg/ml ± ۱۲۸۲.۵۴ and ۱۴۴.۱۶ pg/ml ± ۱۳۷.۹۰ in patients with and without LN respectively. The UMCP-۱ level was significantly higher in group ۲ than group ۱. There was no significant correlation between UMCP-۱ and ۲۴-hour urine protein (r = ۰.۰۳۱, P= ۰.۸۷۴). The area under the ROC curve was ۰.۷۲۷ with a CI ۹۵% of ۰.۵۹۷ to ۰.۸۵۷ (P=۰.۰۰۲). Using a cut-off value of ۸۲ pg/ml,UMCP-۱ had a sensitivity of ۸۸.۵% and a specificity of ۴۶.۳% for identifying LN.ConclusionUMCP-۱ can serve as a biomarker of LN although further longitudinal studies of these biomarkers are required in LN.
کلمات کلیدی: Lupus nephritis, Monocyte chemoattractant protein ۱, systemic lupus erythematosus, Urine
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1297813/