Effect of leptin receptor Q۲۲۳R polymorphism on breast cancer risk

Publish Year: 1393
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJBMS-17-8_008

تاریخ نمایه سازی: 4 آبان 1400

Abstract:

Objective(s):Leptin receptor (LEPR) is a member of the class I cytokine receptor super-family that is known implicated in the initiation and progression of breast cancer. We have investigated the effect of Q۲۲۳R polymorphism on the breast cancer susceptibly in a sample of Iranian subjects. Materials and Methods:We utilized a polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) method to investigate the association ofLEPRQ۲۲۳R polymorphism with breast cancer risk in a case control study consisting of ۱۰۰ breast cancer cases and ۱۰۰ controls without breast cancer. Serum levels of leptin and soluble leptin receptor (sOB-R) were measured by ELISA method. Results:The genotype (QQ, QR, and RR) distributions were ۲۵, ۵۶, and ۱۹ % in breast cancer cases and ۵۴, ۴۰, and ۶% in controls, respectively. The frequency of ۲۲۳ RR genotype was significantly elevated in breast cancer cases as compared to controls (χ۲= ۲۰.۰۷۲, P<۰.۰۰۱). Similar significance differences were also found in allele frequencies for Q and R between two groups (χ۲= ۱۹.۰۲۷, P< ۰.۰۰۱). Additionally, there weresignificant association between Q۲۲۳R genotypes and breast cancer risk; homozygotes for RR genotype (OR= ۶.۸۴۰; ۹۵% confidence interval [CI] = ۲.۴۳۴-۱۹.۲۱۸), heterozygotes for QR (OR=۳.۰۲۴; ۹۵% CI = ۱.۶۲۰-۵.۶۴۴, P = ۰.۰۰۱), and QR+RR genotype (OR= ۳.۵۲۲; ۹۵% CI = ۱.۹۳۴-۶.۴۱۴, P < ۰.۰۰۱), respectively. Conclusion:Our results showed thattheLEPRQ۲۲۳R polymorphism is associated with increased breast cancer risk as well as tumor grade in a sample of Iranian subjects.

Keywords:

Breast Cancer , Leptin receptor rene polymorphism , Polymerase chain reaction , Restriction fragment length polymorphism

Authors

Ghorban Mohammadzadeh

Hyperlipidemia Research Center, Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Mohammad-Ali Ghaffari

Cellular and Molecular Research Center, Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Ahmmad Bafandeh

Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Sayed-Mohammad Hosseini

Department of Radiation and Oncology of Golestan University Hospital, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

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