Year: 1392
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 16، Issue: 3
COI: JR_IJBMS-16-3_014
Language: EnglishView: 52
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Abstract:
The underlying mechanisms leading to the development of human T-cell lymphotropic virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-I infected individuals are not fully understood. Host genetic factors appear to be involved as risk factors for developing HAM/TSP. We investigated the possible contribution of interleukin-۱۰ (IL-۱۰) as a risk factor to HAM/TSP by comparing frequencies of promoter region single nucleotide polymorphisms in HTLV-I infected Iranian patients who either remained asymptomatic or developed HAM/TSP and asymptomatic HTLV-I carriers. Healthy, uninfected individuals from the same region served as healthy controls. Significant differences were observed in the distribution of IL-۱۰ promoter alleles and genotypes at position -۸۱۹ and -۵۹۲ between HAM/TSP patients and healthy controls (P=۰.۰۱), and between HTLV-I carriers and healthy controls (P=۰.۰۲). The frequency of the low IL-۱۰ producer haplotype (-۱۰۸۲*A, -۸۱۹*T, -۵۹۲*A) was significantly associated with HTLV-I carriage or HAM/TSP compared with healthy controls (P= ۰.۰۲ and ۰.۰۱, respectively). Our results suggest that IL-۱۰ -۸۱۹*T and -۵۹۲*A alleles are significant risk factors for developing HTLLV-I infection but do not appear to convey additional risk for developing HAM/TSP
Keywords:
Gene HAM/TSP HTLV-I IL-۱۰ Polymorphisms
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If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:Shirdel, Abbas and Azarpazhooh, Mahmoud Reza and Sahebari, Maryam and Ghanbari, Mohsen and Mirfeizi, Seyedeh Zahra and Hutchinson, Ian and Ziaee, Aghigh and Rafatpanah, Houshang,1392,Association of IL-۱۰ Gene Polymorphisms and Human T Lymphotropic
Virus Type I-Associated Myelopathy/tropical Spastic Paraparesis in
North-East of Iran (Mashhad),https://civilica.com/doc/1297868
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