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Title

Association of IL-۱۰ Gene Polymorphisms and Human T Lymphotropic Virus Type I-Associated Myelopathy/tropical Spastic Paraparesis in North-East of Iran (Mashhad)

مجله علوم پایه پزشکی ایران، دوره: 16، شماره: 3
Year: 1392
COI: JR_IJBMS-16-3_014
Language: EnglishView: 52
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Authors

Abbas Shirdel - Department of Hematology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mahmoud Reza Azarpazhooh - Neurology Department, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Maryam Sahebari - Rheumatic Diseases Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mohsen Ghanbari - Immunology Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Seyedeh Zahra Mirfeizi - Rheumatic Diseases Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Ian Hutchinson - Immunology Research Group, Faculty of Life Sciences, The University of Manchester, United Kingdom
Aghigh Ziaee - Immunology Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Houshang Rafatpanah - Inflammation and Inflammatory Disease Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract:

  The underlying mechanisms leading to the development of human T-cell lymphotropic virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-I infected individuals are not fully understood. Host genetic factors appear to be involved as risk factors for developing HAM/TSP. We investigated the possible contribution of interleukin-۱۰ (IL-۱۰) as a risk factor to HAM/TSP by comparing frequencies of promoter region single nucleotide polymorphisms in HTLV-I infected Iranian patients who either remained asymptomatic or developed HAM/TSP and asymptomatic HTLV-I carriers. Healthy, uninfected individuals from the same region served as healthy controls. Significant differences were observed in the distribution of IL-۱۰ promoter alleles and genotypes at position -۸۱۹ and -۵۹۲ between HAM/TSP patients and healthy controls (P=۰.۰۱), and between HTLV-I carriers and healthy controls (P=۰.۰۲). The frequency of the low IL-۱۰ producer haplotype (-۱۰۸۲*A, -۸۱۹*T, -۵۹۲*A) was significantly associated with HTLV-I carriage or HAM/TSP compared with healthy controls (P= ۰.۰۲ and ۰.۰۱, respectively). Our results suggest that IL-۱۰ -۸۱۹*T and -۵۹۲*A alleles are significant risk factors for developing HTLLV-I infection but do not appear to convey additional risk for developing HAM/TSP  

Keywords:

Gene HAM/TSP HTLV-I IL-۱۰ Polymorphisms

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This Paper COI Code is JR_IJBMS-16-3_014. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1297868/

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Shirdel, Abbas and Azarpazhooh, Mahmoud Reza and Sahebari, Maryam and Ghanbari, Mohsen and Mirfeizi, Seyedeh Zahra and Hutchinson, Ian and Ziaee, Aghigh and Rafatpanah, Houshang,1392,Association of IL-۱۰ Gene Polymorphisms and Human T Lymphotropic Virus Type I-Associated Myelopathy/tropical Spastic Paraparesis in North-East of Iran (Mashhad),https://civilica.com/doc/1297868

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