p۶۳ is more sensitive and specific than ۳۴βE۱۲ to differentiate adenocarcinoma of prostate from cancer mimickers

Objective(s): Prostate cancer is the world’s leading cause of cancer and the second cause of cancer-related death in men after lung cancer. Differentiation of prostate adenocarcinoma from benign prostate lesions and hyperplasia sometimes cannot be done on the basis of morphologic findings. Considering the fact that in the prostate adenocarcinoma there is no basal cell layer, basal cell markers can help to differentiate prostate adenocarcinoma from cancer mimickers. Materials and Methods:We studied ۹۸ prostate biopsy blocks (۴۰ adenocarcinoma and ۵۸ benign lesions) for basal cell marker expression. Results: p۶۳ and ۳۴βE۱۲ were negative in all prostate adenocarcinoma specimens, but all benign prostate hyperplasia and high grade intraepithelial neoplasia cases expressed them. Conclusion: Basal cell markers can help to distinguish prostate adenocarcinoma from cancer mimickers.

Keywords:

Basal cell markers , Cancer mimickers , Prostate adenocarcinoma