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Development of ۱۷۷Lu-phytate Complex for Radiosynovectomy

عنوان مقاله: Development of ۱۷۷Lu-phytate Complex for Radiosynovectomy
شناسه ملی مقاله: JR_IJBMS-16-5_008
منتشر شده در در سال 1392
مشخصات نویسندگان مقاله:

Hassan Yousefnia - Radiopharmaceutical Research and Development Lab, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran, P.O.Box:۱۴۳۹۵-۸۳۶ ۲ Faculty of Energy Engineering and Physics, Amirkabir University of Technology. Tehran, Iran
Amir Reza Jalilian - Radiopharmaceutical Research and Development Lab, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran, P.O.Box:۱۴۳۹۵-۸۳۶
Ali Bahrami-Samani - Radiopharmaceutical Research and Development Lab, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran, P.O.Box:۱۴۳۹۵-۸۳۶
Mohammad Mazidi - Radiopharmaceutical Research and Development Lab, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran, P.O.Box:۱۴۳۹۵-۸۳۶
Mohammad Ghannadi Maragheh۱ - Radiopharmaceutical Research and Development Lab, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran, P.O.Box:۱۴۳۹۵-۸۳۶
Fereydoun Abbasi-Davani - Radiation Application Group, Faculty of Nuclear Engineering, Shahid Beheshti University, Tehran, Iran

خلاصه مقاله:
Objective(s): In this work a new possible agent for radiosynovectomy has been targeted for articular pain palliation. Materials and Methods: Lu-۱۷۷ of ۲.۶-۳ GBq/mg specific activity was obtained by irradiation of natural Lu۲O۳ sample with thermal neutron flux of ۴ × ۱۰۱۳ n.cm-۲.s-۱. The product was converted into chloride form which was further used for labeling of ۱۷۷Lu-phytate complex and checked using ITLC (MeOH: H۲O: acetic acid, ۴: ۴: ۲, as mobile phase). The complex stability and viscosity were checked in the final solution up to seven days. The prepared complex solution (۱۰۰ µCi/۱۰۰ µl) was injected intra-articularly to male rat knee joint. Leakage of radioactivity from injection site and its distribution in organs were investigated up to seven days. Results: The complex was successfully prepared with high radiochemical purity (>۹۹.۹ %). Approximately, the whole injected dose has remained in injection site seven days after injection. Conclusion: The complex was proved to be a feasible agent for cavital radiotherapy in oncology and rheumatology

کلمات کلیدی:
Biodistribution Lutetium-۱۷۷ Phytate Radiosynovectomy

صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1297918/