Production, Quality Control and Biological Evaluation of ۱۶۶Ho-PDTMP as a Possible Bone Palliation Agent

Publish Year: 1392
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJBMS-16-5_010

تاریخ نمایه سازی: 4 آبان 1400

Abstract:

Objective(s):In this study, ۱۶۶Ho-۱,۲-propylene di-amino tetra(methy۱enephosphonicAcid) (۱۶۶Ho-PDTMP) complex  was prepared as a bone palliation agent. Materials and Methods:The complex was successfully prepared using an in-house synthesized EDTMP ligand and ۱۶۶HoCl۳. Ho-۱۶۶ chloride was obtained by thermal neutron irradiation (۱ × ۱۰۱۳ n.cm-۲.s-۱) of natural Ho(NO۳)۳ samples  followed by radiolabeling and stability studies. Biodistribution in wild type rats was also peformed. Results: The complex was prepared with thespecific activity of ۲۷۸ GBq/mg and high radiochemical purity (>۹۹%, checked by ITLC). ۱۶۶Ho-PDTMP complex was stabilized in the final preparation and in the presence of human serum (>۹۰%) up to ۷۲ hr. The biodistribution of ۱۶۶Ho-PDTMP in wild-type rats demonstrated significant bone uptake was up to ۴۸ hr compared to ۱۶۶HoCl۳. Conclusion: The produced ۱۶۶Ho-PDTMP properties suggest a possible new bone palliative therapeutic to overcome the metastatic bone pains.  

Keywords:

Biodistribution ۱۶۶Ho PDTMP Radiopharmaceutical Therapy

Authors

Samaneh Zolghadri

Radiopharmaceutical Research & Development Laboratory (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran ۲ Faculty of Energy Engineering and Physics, Amirkabir University of Technology, Tehran, Iran

Amir Reza Jalilian

Radiopharmaceutical Research & Development Laboratory (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran ۲ Faculty

Zohreh Naseri

Radiopharmaceutical Research & Development Laboratory (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran

Hassan Yousefnia

Radiopharmaceutical Research & Development Laboratory (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran

Ali Bahrami-Samani

Radiopharmaceutical Research & Development Laboratory (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran

Mohammad Ghannadi-Maragheh

Radiopharmaceutical Research & Development Laboratory (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran

Hossein Afarideh

Faculty of Energy Engineering and Physics, Amirkabir University of Technology, Tehran, Iran

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