The Effect of Celecoxib, a Cyclooxygenase-۲ Inhibitor on Noise- Induced Hearing Loss
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 16، Issue: 5
Publish Year: 1392
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-16-5_011
تاریخ نمایه سازی: 4 آبان 1400
Abstract:
Objective(s): Noise-induced hearing loss (NIHL) is the major cause of acquired hearing loss. Celecoxib, a cyclooxygenase-۲ (COX-۲) inhibitor, is a non- steroidal anti- inflammatory drug (NSAID) with known antioxidant and antineoplastic activity. Therefore, we monitored the extent of temporary noise- induced threshold shifts (TTS) and cochlear damage caused by high level ۴- kHz noise exposure to verify the differences with those pretreated with celecoxib. Materials and Methods: Ten male albino guinea pigs (۳۰۰-۳۵۰ g in weight) were randomly allocated into two groups: the primal group was exposed to ۴- kHz octave band noise at ۱۰۲ dB SPL for ۳ hrs (group ۱, n=۵); the latter pretreated with ۵۰ mg/ kg celecoxib for ۳ days, then exposed to noise (group ۲, n=۵). Before exposure and one hr after noise exposure, threshold shifts were evaluated with auditory brainstem responses (ABR) and finally the animals were euthanized for histological evaluation. Results: Comparing the threshold shifts before/after noise exposure with those pretreated, we found out that TTS caused by noise exposure did not show significant mitigation by celecoxib. By observing the organ of Corti at lower middle turn of cochlea in celecoxib pretreated group, considerable hair cell loss was discovered. Conclusion:The current study clearly confirmed that celecoxib had no attenuation against temporary noise-induced hearing loss.
Keywords:
Auditory brainstem responses Celecoxib Guinea pigs Hair cell Threshold shift Noise-induced hearing loss
Authors
Akram Pourbakht
Department of Audiology, Faculty of Rehabilitation, Rehabilitation Research Center, Iran University of Medical Sciences, Tehran, Iran
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