Genetic Variations of Tumor Necrosis Factor –α-۳۰۸ and Lymphtoxin-α+۲۵۲ in Non-Hodgkin Lymphoma and Acute Lymphoblastic Leukemia Patients

Publish Year: 1392
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJBMS-16-9_007

تاریخ نمایه سازی: 4 آبان 1400

Abstract:

  Objective(s): Non- Hodgkin lymphoma (NHL) and acute lymphoblastic leukemia (ALL) are two main hematological malignances which have been driven from lymphoid tissue. Genetic polymorphisms in tumor necrosis factor-α (TNF-α) -۳۰۸ and lymphotoxin-α (LT-α) +۲۵۲ may affect their transcription and expression which leads to their high plasma level. The frequency of the TNF-α (-۳۰۸) and LT-α (+ ۲۵۲) polymorphisms are different for NHL and ALL cases in various populations with different ethnicity. This research is designed to investigate the prevalence and association of TNF-α (-۳۰۸) and LT-α (+ ۲۵۲) polymorphisms from NHL and ALL in Azarian patients and healthy individuals from Northwestern part of Iran.   Materials and Methods: Seventy subjects with ALL and ۶۸ NHL, along with another ۱۳۰ healthy subjects as control group took part in this study. Genomic DNA was extracted, then genetic polymorphisms in TNF-α and LT-α genes were analyzed with the PCR-RFLP and NCOI as restriction enzyme. A statistical analysis was performed by chi-square test using SPSS software. A P-value of <۰.۰۵ was considered statistically significant. Results: A statistically significant difference of LT-α polymorphism was in NHL patients and control (P-value= ۰.۰۰۸) but there was not any association of TNF-α polymorphism between NHL patients and control group. A significant association for TNF-a variant was in ALL and control (P-value =۰.۰۰۵), however, there was no relationship about LT variant between ALL and control. Conclusion: The results show that there are significant differences between TNF-α (-۳۰۸) and LT-α (+۲۵۲) genetic polymorphisms respectively in ALL and NHL patients with control group from Northwestern part of Iran.

Keywords:

Acute lymphocytic leuke- mia LT-α Non-Hodgkin lymphoma Polymorphism TNF-α

Authors

Hajar Nasiri

School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Safar Farajnia

Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Azim Rezamand

Childeren Hospital, Tabriz University of Medical Sciences, Tabriz, Iran

Ali Akbar MovassaghPour

School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Heydar Ali Esmaeili

School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Amir Monfaredan

Tabriz branch, Islamic Azad University of Medical Science, Tabriz, Iran

Naser Mobarra

Clinical Biochemistry Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Nasser Rahimifar

School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Leyla Sahebi

Tuberclosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Majid Farshdousti Hagh

Hematology & Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

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