Teratogenic Effects of Pregabalin in Mice

Publish Year: 1392
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJBMS-16-10_005

تاریخ نمایه سازی: 4 آبان 1400

Abstract:

  Objective(s): Anti-epileptic drugs (AEDs) have the potential to affect fetal development throughout pregnancy. Considering the broad therapeutic indications of pregabalin (PGB), its potential teratogenic effects and the levels of homocysteine have been studied.   Materials and Methods: Timed-pregnant mice received one of three doses of PGB (۲۰, ۴۰ or ۸۰ mg/kg/day) or the vehicle control during organogenesis, intraperitoneally. The litters were stained and examined for malformations. Total homocysteine (tHcy) was measured in serum from the pregnant mice on GD۱۸. Results: The rate of fetus malformations increased significantly in all treated groups as compared to the control group. The abnormalities included limb, vertebral column and craniofacial abnormalities. The most common abnormality was limb deformity. The percentage of fetal resorption significantly increased at higher doses. There was no significant difference in tHcy concentrations between the treated and control groups. Conclusion: Pregabalin may have potential teratogenic effects even in lower doses, however with less intensity than other AEDs. Therefore, it is suggested that great caution should be taken when prescribing it in pregnancy and further investigation for possible mechaninsms.

Keywords:

Antiepileptic drugs Developmental toxicity Homocysteine Teratogenicity

Authors

Leila Etemad

Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Afshar Mohammad

Department of Anatomy, Birjand University of Medical Sciences, Birjand, Iran ۳ Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Amir Hooshang Mohammadpour

Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.Departments of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Nasser Vahdati Mashhadi

Departments of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Seyed Adel Moallem

Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran ۴ Departments of Pharmacodynamics and Toxicology, School of Pharmacy,

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