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Title

Glutathione s-transferase M۱ and T۱ genetic polymorphisms in Iranian patients with glaucoma

Year: 1393
COI: JR_IJBMS-17-5_004
Language: EnglishView: 53
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Authors

Fatemeh Kazemi Safa - Department of Health, Kermanshah University Medical of Sciences, Kermanshah, Iran
Gholamreza Shahsavari - Lorestan University Medical of Sciences, Khoram Abad, Iran
Reza Zare Abyaneh - Tehran University Medical of Sciences, Tehran, Iran

Abstract:

Objective(s):Glaucoma is the second leading cause of blindness and it is related to oxidative stress based on numerous studies. Glutathione S-transferases (GSTs) are members of multigenic family, which have important role in cells as an antioxidant. In the present study, we examined the polymorphism of GSTT۱ and GSTM۱ deletion genotypes (T۰M۱, T۱M۰, and T۰M۰) in ۱۰۰ Glaucoma patients (۴۱with primary open angle glaucoma (PCAG), and ۵۹ with primary closed angle glaucoma (POAG)) compared to ۱۰۰ healthy subjects. Materials and Methods: GSTM۱and GSTT۱ polymorphisms were determined by multiplex polymerase chain reaction. Results: GSTM۱ and GSTT۱ null deletions genotypes were determined in ۲۲ (۵۳.۷%) and ۷ (۱۷.۱%) patients with PCAG and ۳۴ (۳۴%) and ۱۵ (۱۵%) in healthy subjects[VAIO۱] . Comparison between patients and healthy subjects regarding GSTM۱ and GSTT۱ genotypes revealed increase of GSTM۱ null deletions genotypes in patients with PCAG (P=۰.۰۳). Conclusion: It was concluded that the increased frequencies of GSTM۱ null in patients with PCAG could be a risk factor for incidence of PCAG in the Iranian population.  

Keywords:

glaucoma , Glutathione s-transferases , Primary closed angle glaucoma , Primary open angle glaucoma

Paper COI Code

This Paper COI Code is JR_IJBMS-17-5_004. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1298045/

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If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Kazemi Safa, Fatemeh and Shahsavari, Gholamreza and Zare Abyaneh, Reza,1393,Glutathione s-transferase M۱ and T۱ genetic polymorphisms in Iranian patients with glaucoma,https://civilica.com/doc/1298045

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  • Sacca SC, Izzotti A, Rossi P, Traverso C. Glaucomatous outflow ...
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COI stands for "CIVILICA Object Identifier". COI is the unique code assigned to articles of Iranian conferences and journals when indexing on the CIVILICA citation database.

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