Glutathione s-transferase M۱ and T۱ genetic polymorphisms in Iranian patients with glaucoma
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 17، Issue: 5
Publish Year: 1393
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-17-5_004
تاریخ نمایه سازی: 4 آبان 1400
Abstract:
Objective(s):Glaucoma is the second leading cause of blindness and it is related to oxidative stress based on numerous studies. Glutathione S-transferases (GSTs) are members of multigenic family, which have important role in cells as an antioxidant. In the present study, we examined the polymorphism of GSTT۱ and GSTM۱ deletion genotypes (T۰M۱, T۱M۰, and T۰M۰) in ۱۰۰ Glaucoma patients (۴۱with primary open angle glaucoma (PCAG), and ۵۹ with primary closed angle glaucoma (POAG)) compared to ۱۰۰ healthy subjects. Materials and Methods: GSTM۱and GSTT۱ polymorphisms were determined by multiplex polymerase chain reaction. Results: GSTM۱ and GSTT۱ null deletions genotypes were determined in ۲۲ (۵۳.۷%) and ۷ (۱۷.۱%) patients with PCAG and ۳۴ (۳۴%) and ۱۵ (۱۵%) in healthy subjects[VAIO۱] . Comparison between patients and healthy subjects regarding GSTM۱ and GSTT۱ genotypes revealed increase of GSTM۱ null deletions genotypes in patients with PCAG (P=۰.۰۳). Conclusion: It was concluded that the increased frequencies of GSTM۱ null in patients with PCAG could be a risk factor for incidence of PCAG in the Iranian population.
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Authors
Fatemeh Kazemi Safa
Department of Health, Kermanshah University Medical of Sciences, Kermanshah, Iran
Gholamreza Shahsavari
Lorestan University Medical of Sciences, Khoram Abad, Iran
Reza Zare Abyaneh
Tehran University Medical of Sciences, Tehran, Iran
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