Stress during first pregnancy increases seizure threshold in adult male offspring
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 17، Issue: 1
Publish Year: 1392
نوع سند: مقاله ژورنالی
زبان: English
View: 138
This Paper With 7 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_IJBMS-17-1_006
تاریخ نمایه سازی: 5 آبان 1400
Abstract:
Objective(s): Stress induces many homeostatic aberrations which are followed by lifelong allostatic responses. Epilepsy is developed or influenced by different environmental factors, i.e. prenatal stress which makes many contradictory developmental changes in seizure threshold and intensity. We investigated the potential seizure response of the rat offspring to prenatal stress; the stress which was applied to their mothers. Materials and Methods: Nine day heterogeneous sequential stress (HSS) model was used before and during the first and before the second pregnancy. The kindling was induced using ۱۳ IP injections of pentylenetetrazol (PTZ) every ۴۸ hr to adult male Wistar rat's offspring. Results: The results of the present study demonstrated that, before pregnancy stress decreased the rate of kindling (P<۰.۰۵) in the offspring, while stress which was applied during pregnancy completely prevented kindling (P <۰.۰۰۱). Further, their convulsive latency was increased and tonic clonic seizure duration was decreased. In contrast, previous pregnancy and between pregnancies stress could not change kindling process. Although maternal separation stress did not change kindling development, it could increase convulsive intensities by elongating the duration of seizures (P<۰.۰۵) and reducing convulsion latency (P <۰.۰۵). Conclusion: It is concluded that stress detrimental effects could be prevented by stress which was applied around first pregnancy; however this beneficial effect is weakened by before second pregnancy stress.
Keywords:
Authors
Peyman Pajand
Azad Islamic University-Damghan Branch, Damghan, Iran
Mahmoud Elahdadi Salmani
School of Biology, Damghan University, Damghan, Iran ۳ Institute of Biological Sciences, Damghan University, Damghan, Iran
Hooman Shajiee
Azad Islamic University-Damghan Branch, Damghan, Iran
Hasan Abiri
Azad Islamic University-Damghan Branch, Damghan, Iran
Iran Goudarzi
School of Biology, Damghan University, Damghan, Iran ۳ Institute of Biological Sciences, Damghan University, Damghan, Iran
Kataneh Abrari
School of Biology, Damghan University, Damghan, Iran ۳ Institute of Biological Sciences, Damghan University, Damghan, Iran
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :