Assessment of HTLV-I proviral load, HIV viral load and CD۴ T cell count in infected subjects; with an emphasis on viral replication in co-infection

Publish Year: 1392
نوع سند: مقاله ژورنالی
زبان: English
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JR_IJBMS-17-1_008

تاریخ نمایه سازی: 5 آبان 1400

Abstract:

  Objective(s): HTLV-I and HIV virus quantification is an important marker for assessment of virus activities. Since there is a direct relationship between the number of virus and disease progression, HTLV- I and HIV co-infection might have an influence on the development of viral associated diseases, thus, viral replication of these viruses and co-infection were evaluated.   Materials and Methods: In this study, ۴۰ subjects were selected; ۱۴ HIV infected, ۲۰ HTLV-I infected and ۶ HTLV-I/HIV co-infected subjects. The amount of viruses was measured using qPCR TaqMan method and CD۴ and CD۸ lymphocytes were assessed by flow cytometry. Results: The mean viral load of HIV infected subjects and HTLV-I infected individuals were ۱۳۴۶۲۶.۰۷±۶۰۰۳۱.۰۷ copies/ml and ۳۷۳.۶±۱۴۳.۳ copies/۱۰۴ cells, respectively. The mean HIV viral load in co-infected group was ۱۵۸۹۴۷±۷۸۲۰۳.۵۹ copies/ml which is higher than HIV infected group. The mean proviral load of HTLV-I in co-infected group was ۲۲۲.۳۳±۸۲.۵۶ copies/ml which is lower than HTLV-I infected group (P<۰.۰۵). Also, the mean white blood cell count was higher in co-infected group (۵۶۶۶.۶۷±۱۱۴۶.۴۹ cells/μl). However, the differences between these subjects did not reach to a statistical significance within ۹۵% confidence interval level (P =۰.۱). No significant differences were observed regarding CD۴ and CD۸ positive lymphocytes between these groups.   Conclusion: HTLV-I/HIV co-infection might promote HIV replication and could reduce the HTLV-I proviral load, in infected cells. Considering the presence of both viruses in Khorasan provinces, it encourages researchers and health administrators to have a better understanding of co-infection outcome.

Authors

Hossein Rahimi

Hematology Department, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Seyyed Abdolrahim Rezaee

Immunology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Narges Valizade

Inflammation and Inflammatory Diseases Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Rosita Vakili

Inflammation and Inflammatory Diseases Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Houshang Rafatpanah

Inflammation and Inflammatory Diseases Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

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