The Relationship Between Salivary Dehydroepiandrosterone Sulphate (DHEAS) Levels and Skeletal Maturation Parameters Before and During Pubertal Growth Spurt in Children

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نوع سند: مقاله ژورنالی
زبان: English
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JR_ORTHO-15-2_003

تاریخ نمایه سازی: 12 آبان 1400

Abstract:

Objectives This study aimed to assess the skeletal maturation by using salivary DHEAS levels and its correlation with existing skeletal maturity parameters represented by cervical vertebrae and MP۳ region radiographs in adolescents in pre-pubertal and pubertal age groups. Methods In this study, ۸۰ children in the age range of ۸ - ۱۴ years were divided into two equal groups based on their chronological age as group I (pre-pubertal group) and group II (pubertal group). Pre-existing lateral cephalograms and medial phalanx of third finger (MP۳) radiographs of their left hands were assessed. The levels of the DHEAS of each individual were analysed by ELISA kit. ANOVA with post-hoc Tukey’s test and student t-test were used for statistical analysis. P-value < ۰.۰۵ was considered significant. Results The mean level of DHEAS values shown in the present study was ۴.۳۶ +/- ۰.۳۲ ng/mL in group I and ۵.۷۳+/-۰.۳۹ ng/mL in group II. This study showed that in group I, more subjects were in stage ۱ of cervical vertebral maturation than stage ۲ and there were significant differences between the two stages (P-value = ۰.۰۱۱); also, in group II, more subjects were in stage ۳ than ۴ and there were significant differences between the two stages (P-value = ۰.۰۱۷). This study revealed the highest salivary DHEAS levels to be in the F stage of pre-pubertal MP۳ development in addition to the H stage of MP۳ development in pubertal children. This study noted that there were significant differences for salivary DHEAS levels between males and females not only in pre-pubertal (P-value = ۰.۰۳۱), but also in pubertal stages (P-value < ۰.۰۰۱). Conclusions Salivary DHEAS, like cervical vertebra and MP۳ radiographs, can be used for growth assessment in young adolescents.

Authors

Tahseen Sultana

Department of Paediatric and Preventive Dentistry, Government Dental College and Hospital, Hyderabad, India

Penmetcha Sarada

Department of Pedodontics and Preventive Dentistry, Sri Sai College of Dental Surgery, Vikarabad, India

Namineni Srinivas

Department of Pedodontics and Preventive Dentistry, Sri Sai College of Dental Surgery, Vikarabad, India

C H Sampath Reddy

Department of Pedodontics and Preventive Dentistry, Sri Sai College of Dental Surgery, Vikarabad, India

S Ojass KUMAR

Department of Orthodontics and Dentofacial Orthopaedics, Government Dental College and Hospital, Hyderabad, India

Shaik Hasanuddin

Department of Paediatric and Preventive Dentistry, Government Dental College and Hospital, Hyderabad, India