Urinary EGF level Changes in Hydronephrotic Infant Patients before and after Surgery

Background: Urinary tract obstruction is defined as any disorder in the normal urinary flow tract in the pediatric group. In the field of urology, urine stasis and urinary obstructions play an important role in renal complications. Every obstruction in the urinary tract can lead to hydronephrosis, atrophy and even full destruction of renal function. In addition, tract obstruction can result in a urinary infection which exacerbates the destruction per se.Methods: The present study was a descriptive-analytical study of ۲۵ one-month-old to one-year-old children. In this study, one urine sample was collected the day before surgery, another urinary sample was taken from the affected pelvis during surgery, and the other urine sample was collected at the time of double J exertion and stored at a suitable temperature (minus ۷۰. C). The EGF factor was measured in the collected samples, by the use of ELISA method.Results: The findings revealed that the urinary level of EGF was significantly reduced after surgery, so that the average level of this marker before surgery for the study population was ۴۰.۱۲±۱۲.۵۵, while this amount after surgery equaled ۳۷.۳۲±۱۱.۵۱ mg/dL. The analysis of the data by the T test showed a significant relationship between EGF level and the time of measurement (P=۰.۰۰۰۱).Conclusion: The results of the above study show that obstruction of the urinary tract can increase the urinary level of EGF; and with increasing age, the amount of this marker increases in children who have obstruction of the urinary tract.

Keywords:

EGF , hydronephrosis , urinary