ناشر تخصصی کنفرانس های ایران

لطفا کمی صبر نمایید

Publisher of Iranian Journals and Conference Proceedings

Please waite ..
Publisher of Iranian Journals and Conference Proceedings
Login |Register |Help |عضویت کتابخانه ها
Paper
Title

Role of Caspase-۳ Level in Perinatal Asphyxia

Role of Caspase-۳ Level in Perinatal Asphyxia
Year: 1400
COI: JR_IRJN-12-4_001
Language: EnglishView: 22
This Paper With 7 Page And PDF Format Ready To Download

Buy and Download

با استفاده از پرداخت اینترنتی بسیار سریع و ساده می توانید اصل این Paper را که دارای 7 صفحه است به صورت فایل PDF در اختیار داشته باشید.
آدرس ایمیل خود را در کادر زیر وارد نمایید:

Authors

Johnny Rompis - Department of Pediatrics, Faculty of Medicine, Sam Ratulangi University, Manado, North Sulawesi, Indonesia
Darmawan Murdono - Department of Pediatrics, Faculty of Medicine, Sam Ratulangi University, Manado, North Sulawesi, Indonesia
Dasril Daud - Department of Pediatrics, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Rocky Wilar - Department of Pediatrics, Faculty of Medicine, Sam Ratulangi University, Manado, North Sulawesi, Indonesia
Mochammad Hatta - Department of Molecular Biology and Immunology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Adrian Umboh - Department of Pediatrics, Faculty of Medicine, Sam Ratulangi University, Manado, North Sulawesi, Indonesia

Abstract:

Background: Perinatal asphyxia is the main cause of neurodevelopmental sequelae and perinatal death. Caspase-۳ is a major enzyme associated with apoptosis and increases in hypoxic-ischemic events. There is still no reliable biomarker to predict the severity and outcome of an asphyxial event. In this regard, this study aimed to determine the caspase-۳ level and its role as an outcome predictor in perinatal asphyxia. Methods: This paired-group observational analytical cross-sectional study lasted from September ۲۰۱۶ to February ۲۰۱۷. In total, ۵۰ neonates were included in the research and Caspase-۳ levels were examined at two different times. Student’s t-test and logistic regression analysis were used for statistical analysis.Results: There were ۲۳ neonates (۴۶%) with hypoxic-ischemic encephalopathy (HIE) and an increase in Caspase-۳ level by ۰.۳۱۳۵ points from the first to the second examination (t=۶.۵۵۵; P<۰.۰۰۰۱). Results of this study showed a significant correlation between the caspase-۳ level and mortality in neonates with HIE during both the initial (RR=۲.۳۳; P=۰.۰۱۴) and subsequent examinations (RR=۲.۲۵; P=۰.۰۱۵). Conclusion: There is a significant increase in Caspase-۳ levels in infants who suffer from perinatal asphyxia which can predict mortality in neonates with HIE.  

Keywords:

Paper COI Code

This Paper COI Code is JR_IRJN-12-4_001. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1313077/

How to Cite to This Paper:

If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Rompis, Johnny and Murdono, Darmawan and Daud, Dasril and Wilar, Rocky and Hatta, Mochammad and Umboh, Adrian,1400,Role of Caspase-۳ Level in Perinatal Asphyxia,https://civilica.com/doc/1313077

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :

  • Ghaffaripour HA, Jalali M, Nikravesh MR, Seghatoleslam M, Sanchooli J. ...
  • Odd D, Heep A, Luyt K, Draycott T. Hypoxic-ischemic brain ...
  • Maternal and newborn health disparities: Indonesia. UNICEF. Available at: URL: ...
  • org/resources/maternal-newborn-health-disparities-country-profiles/; ۲۰۱۶ ...
  • Hankins GD, Speer M. Defining the pathogenesis and pathophysiology of ...
  • Gomella TL, Cunningham MD, Eyal FG, Tuttle DJ. Neonatology: management, ...
  • Northington FJ, Chavez-Valdez R, Martin LJ. Neuronal cell death in ...
  • Kamelia E, Islam AA, Hatta M, Kaelan C, Patelongi I. ...
  • Miko H, Islam A, Hatta M. Evaluation of caspase-۳ mRNA ...
  • Lorente L, Martín MM, Argueso M, Ramos L, Solé-Violán J, ...
  • Lee JM, Zipfel GJ, Choi DW. The changing landscape of ...
  • Nicholson DW, Thornberry NA. Caspases: killer proteases. Trends Biochem Sci. ...
  • Troy CM, Akpan N, Jean YY. Regulation of caspases in ...
  • Ma J, Endres M, Moskowitz MA. Synergistic effects of caspase ...
  • Deng C, Li J, Li L, Sun F, Xie J. ...
  • Blomgren K, Zhu C, Wang X, Karlsson JO, Leverin AL, ...
  • Delivoria-Papadopoulos M, Ashraf QM, Ara J, Mishra OP. Nuclear mechanism ...
  • Namura S, Zhu J, Fink K, Endres M, Srinivasan A, ...
  • Research Info Management

    Certificate | Report | من نویسنده این مقاله هستم

    اطلاعات استنادی این Paper را به نرم افزارهای مدیریت اطلاعات علمی و استنادی ارسال نمایید و در تحقیقات خود از آن استفاده نمایید.

    Share this page

    More information about COI

    COI stands for "CIVILICA Object Identifier". COI is the unique code assigned to articles of Iranian conferences and journals when indexing on the CIVILICA citation database.

    The COI is the national code of documents indexed in CIVILICA and is a unique and permanent code. it can always be cited and tracked and assumed as registration confirmation ID.

    Support