Accuracy of Urine Calprotectin in the Diagnosis of Acute Kidney Injury in Neonates: A Cross-Sectional Study

Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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JR_IRJN-12-4_002

تاریخ نمایه سازی: 23 آبان 1400

Abstract:

Background: Urine calprotectin significantly elevates in acute kidney injury (AKI) in adult and pediatric patients. The present study aimed to assess the accuracy of urine calprotectin as a diagnostic marker for (AKI) in neonates.Methods: This cross-sectional study assessed urine calprotectin in ۱۰۰ neonates (۸۰ newborns with confirmed AKI and ۲۰ healthy ones). Random urine calprotectin was measured by Enzyme-linked Immunosorbent Assay (ELISA) and then compared between the two groups. We included the neonates who had received at least ۴۸ h of intravenous fluid and met the inclusion and exclusion criteria. Receiver-operating characteristic (ROC) curve was used to set a cut-off point for urine calprotectin for the prediction of AKI. The overall accuracy and Kappa coefficient were used to assess the agreement between the two methods. A p-value less than ۰.۰۵ was considered statistically significant. Results: Urine calprotectin levels were not significantly higher in neonates with AKI, as compared to those in the healthy ones (۱۴۶.۲ versus ۱۴۲.۴; P=۰.۱). The results pointed to an optimal cut-off value of ۱۲۳.۵ mg/dl for urine calprotectin with the area under the curve of ۰.۵۱۵ (the sensitivity, specificity, positive predictive value, and negative predictive value were obtained at ۷۷.۵%, ۴۰%, ۸۳.۷%, and ۳۰.۷%, respectively). The overall accuracy and Kappa agreement coefficient were reported as ۷۰% and ۰.۱۵, r (P=۰.۱۱). Conclusion: As evidenced by the results of the resent study, although urine calprotectin level elevates in AKI in neonates, it is not more sensitive than gold standards to predict AKI.  

Authors

Nasrin Khalesi

Department of Pediatrics, Ali Asghar Hospital, Iran University of Medical Sciences, Tehran, Iran

Shima Mohammadian

Aliasghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran

Nakysa Hooman

Department of Pediatric Nephrology, Aliasghar Children Research Development Center (ACRDC), Iran University of Medical Sciences, Tehran, Iran

Mahmoud Khodadost

Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran & Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran

Leila Allahqoli

Iran University of Medical Sciences, Tehran, Iran

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