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Title

Effects of autologous peripheral blood mononuclear cells on implantation and pregnancy rate in patients with repeated implantation failure

Effects of autologous peripheral blood mononuclear cells on implantation and pregnancy rate in patients with repeated implantation failure
Year: 1400
COI: ICMWMI05_016
Language: EnglishView: 62
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Authors

P Mousavi Mehr - BSc, Novin fertility center, Mashhad, Iran- Ferdowsi University of Mashhad, Mashhad, Iran
M Fadavi Islam - Ms, Novin fertility center, Mashhad, Iran
H Roustaei - MD, Novin fertility center, Mashhad, Iran
M Mansuri Torshizi - MD, Novin fertility center, Mashhad, Iran
Z Bazri - MD, Novin fertility center, Mashhad, Iran
R Mahdavian Zadeh - Ms, Novin fertility center, Mashhad, Iran

Abstract:

Introduction: Repeated implantation failure (RIF) is a major concern in reproductive medicine, despite several methods that have been described for management. Dysfunction of embryo-maternal immuno-tolerance pathways can be one of the reasons of RIF. It has been suggested that uterine natural killer cells are involved in establishment and maintenance of pregnancy and fetus through producing a range of cytokines. To reach this goal, we used endometrium Immuno-modulation prior to frozen embryo transfer for patients with repeated implantation failures.Material and methods: peripheral blood mononuclear cells (PBMC) were isolated from RIF patients, cultured for ۳ days and transferred into their uterus about two days before embryo transfer (ET). This method was performed on ۶۸ patients and compared with ۸۳ patients as control group.Results: pregnancy rate was significantly increased in experimental group versus the control group (۵۸.۸% vs ۴۱.۲%, P= ۰.۰۴). Implantation rate in PBMC group was higher than the control group, but this increase was not statistically significant. Perhaps this could be achieved by increasing cases.Conclusion: Our study demonstrates that intrauterine insemination of PBMC increases pregnancy rates and can be used in RIF patients.

Keywords:

in vitro fertilization , peripheral blood mononuclear cells , uterine natural killer cells , repeated implantation failure , embryo implantation

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This Paper COI Code is ICMWMI05_016. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

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Mousavi Mehr, P and Fadavi Islam, M and Roustaei, H and Mansuri Torshizi, M and Bazri, Z and Mahdavian Zadeh, R,1400,Effects of autologous peripheral blood mononuclear cells on implantation and pregnancy rate in patients with repeated implantation failure,Fifth International Conference on New Findings in Midwifery, Obstetrics, Gynecology and Infertility,https://civilica.com/doc/1319102

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Paper count: 32,968
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