The Role of Garlic Oil in Improving Disturbances in Blood Parameters Caused by Zinc Oxide Nanoparticles

Industrial applications of zinc oxide nanoparticles (ZnO-NPs) are increasing because of their unique features, such as their widespread use in cosmetics as well as sun screens. The potential harmful effects of ZnO-NPs need to be investigated further. The purpose of this research is to examine the prophylactic effect of garlic oil on some hematological parameters altered by zinc oxide nanoparticles (ZnO-NPs) of adult male rats. This experiment was conducted on thirty-six male rats fall into ۴ packs of six animals each. CON is the control group of healthy rats. ZnO-NPs group received ۲۰۰ mg/kg zinc oxide nanoparticles, while the ZnO-NPs +GO group intoxicated rats received ۱۰۰ ml/kg garlic oil, and GO group rats received only ۱۰۰ ml/kg garlic oil. Study duration was ۱۵ days. After the experimentation, rats were sacrificed and the levels of hematological parameters were evaluated, which included erythrocytes count, hemoglobin level, leukocytes count, and platelet count. The results of this study showed that zinc oxide led to significant changes in blood parameters, and when combined with garlic oil, hematological toxicity was improved. In conclusion, the hematological toxicity of ZnO-NPs was noticeable; however, the use of doses of garlic oil reduced this toxic effect.

Keywords:

Blood Toxicity , Garlic oil , Experiment