Olga A. Sunyaikina - Biological chemistry department, FGBEE HE «Kursk State Medical University» (KSMU) ۳۰۵۰۴۰, Russian Federation, Kursk city, K. Marx Street ۳
Aleksey A. Konoplya - Biological chemistry department, FGBEE HE «Kursk State Medical University» (KSMU) ۳۰۵۰۴۰, Russian Federation, Kursk city, K. Marx Street ۳
Irina I. Kolomoets - Biological chemistry department, FGBEE HE «Kursk State Medical University» (KSMU) ۳۰۵۰۴۰, Russian Federation, Kursk city, K. Marx Street ۳
Vera A. Ragulina - Biological chemistry department, FGBEE HE «Kursk State Medical University» (KSMU) ۳۰۵۰۴۰, Russian Federation, Kursk city, K. Marx Street ۳
Tatiana M. Grigorieva - Biological chemistry department, FGBEE HE «Kursk State Medical University» (KSMU) ۳۰۵۰۴۰, Russian Federation, Kursk city, K. Marx Street ۳

This study dealt with women of childbearing age with infertility against the background of the chronic inflammatory process in the stage of incomplete clinical remission, pronounced changes from pro, anti-inflammatory, regulatory cytokines, components and inhibitors of the complement system. Changes in the architectonics of proteins lead to serious functional disorders properties of peripheral blood erythrocytes in chronic kidney disease even in remission. The composition of blood plasma changes significantly during pathology, which in turn has a significant effect on cell morphology, lipid-protein interactions and the latter-related activity of its enzyme systems. There is a "tension" of the immune and metabolic statuses, which can serve to assess the severity of the disease, its prognosis, treatment effectiveness and preventive measures.  "Women with infertility in chronic endometritis and infertility in kidney disease with infertility" was published by the European Society for Human Reproduction and Developmental Disorder (ESDD) in May ۲۰۱۳. The study found that despite the absence of clinical manifestations of inflammation, there was a destructive immune-inflammatory process that requires mandatory correction.

chronic endometritis, demographic situation, fertilization, Reproductive Health