Study of heterocyclic-fused pyridazinone analogues having phosphodiestrase-IV inhibitor activities as anti-inflammatory agents

Phosphodiesterase-IV (PDE- IV) inhibitors which are effective anti-inflammatory agents have forced researchers to find new PDE-IV inhibitors with less adverse effects than conventional anti-inflammatory drugs. Some pyridazinone derivatives reduced inflammation by inhibiting PDE-IV enzyme and acted as anti-inflammatory agents. The new pyridazinone derivatives will be more suitable than the currently developed pyridazinone compounds for future studies and could be developed as more safe anti-inflammatory drugs for humans.

Keywords:

Phosphodiesterase-۴ inhibitor , Inflammation , Pyridazinone derivatives