Mohammad Asif - Department of Pharmacy, Guru Ram Das (PG) Institute of Management and Technology, Dehradun, (Uttarakhand), ۲۴۸۰۰۹, India
. Abida - Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, Rafha ۹۱۹۱۱, PO Box ۸۴۰, Saudi Arabia
Md. Tauquir Alam - Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, Rafha ۹۱۹۱۱, PO Box ۸۴۰, Saudi Arabia

Phosphodiesterase-IV (PDE- IV) inhibitors which are effective anti-inflammatory agents have forced researchers to find new PDE-IV inhibitors with less adverse effects than conventional anti-inflammatory drugs. Some pyridazinone derivatives reduced inflammation by inhibiting PDE-IV enzyme and acted as anti-inflammatory agents. The new pyridazinone derivatives will be more suitable than the currently developed pyridazinone compounds for future studies and could be developed as more safe anti-inflammatory drugs for humans.

Phosphodiesterase-۴ inhibitor, Inflammation, Pyridazinone derivatives