Detoxification of acetaminophen overdose using formulated carbo tablets
Publish place: Journal of Medicinal and Chemical Sciences، Vol: 3، Issue: 2
Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JMCH-3-2_010
تاریخ نمایه سازی: 8 آذر 1400
Abstract:
Acetaminophen overdose is one of severe global health challenges. In this study, adsorption technique was used to reduce acetaminophen overdose. Carbo tablets derived by wet granulation technique, coded as formulated carbo tablet (FCT) and alginated formulated carbo tablets (FCT-Alg), were characterized using the pharmaceutical drug procedures (hardness, disintegration time, tablet strength, friability) and instrumental techniques including, FTIR, SEM, and DSC analysis. DSC thermogram revealed that, the excipients were compatible with the active pharmaceutical ingredient (API). Batch adsorption experiments were carried out in the simulated gastric fluid (SGF) to monitor the role of some parametric factors (pH, concentration, carbo dosages, and PCM dosages). The tablet displayed favorable hardness and disintegration time (۳.۴۰ min). Optimum adsorption was observed at pH ۱.۲ for FCT in SGF (RE of ۹۲.۸۰%); FCT-Alg in SGF (RE of ۹۹.۱۷%). The results depicted that, the adsorption of the acetaminophen in SGF gave up to ۹۹.۶۵% removal efficiency, and compared with the commercial carbo tablet (CCT) with adsorption efficiency of ۹۶.۴۴%.
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Authors
A.U. Itodo
Department of Chemistry, Federal University of Agriculture, PMB ۲۳۷۳ Makurdi, Nigeria
S Ande
Department of Chemistry, Federal University of Agriculture, PMB ۲۳۷۳ Makurdi, Nigeria
M.O. Audu
Department of Chemistry, Federal University of Agriculture, PMB ۲۳۷۳ Makurdi, Nigeria
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