Bone turnover markers are a predictor of Bone Mineral Density in active middle-aged men

The relationship between bone turnover markers and BMD in active men is unclear. We investigated the relationship between bone specific alkaline phosphatase (BAP), Levels of serum osteocalcin (OC) and BMD at various skeletal sites in active Iranian middle age men. A study was conducted on ۱۲۵ active men over the age of ۴۵ to ۷۰ years. BMD at the spine and left forearm were measured with a DXA. Levels of serum osteocalcin (OC) and bone specific alkaline phosphatase (BAP) were determined. SPSS version ۲۶ (Statistical Package for Social Sciences) was used for data analysis. Shapiro-Wilk’s statistics was used to check normality of data. Pearson correlation coefficient was used to find the relationship between body mass index and lumbar bone mineral density. BMD at the spine and proximal femur had significant negative correlation with serum OC (r=−۰.۳۹۵ to −۰.۵۳۰) and BAP (r=−۰.۲۹۷ to −۰.۴۸۶). This study indicated the correlation between specific alkaline phosphatase (BAP) and BMD in active middle-aged men and suggested that serum OC and BAP are the key determining factors of BMD decreases and also suggested that physical activity is associated with BMD.

Keywords:

Bone mineral density , Osteocalcin , Alkaline phosphatase , active , men