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Title

Vitamin E Pretreatment of Mesenchymal Stem Cells: The Interplay of Oxidative Stress and Inflammation

Year: 1399
COI: JR_JCMR-11-2_007
Language: EnglishView: 53
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Authors

Shadi Mehrzad - Department of Biology, Faculty of science, Hakim Sabzevari University, Sabzevar, Iran
Sepideh sadat Hosseini - Department of Biology, Faculty of science, Hakim Sabzevari University, Sabzevar, Iran
Madjid Momeni-Moghaddam - Department of Biology, Faculty of science, Hakim Sabzevari University, Sabzevar, Iran
Moien Farshchian - Stem Cells and Regenerative Medicine Research Department, Academic Center for Education, Culture and Research (ACECR)-Khorasan Razavi, Mashhad, Iran
Halimeh Hassanzadeh - Stem Cells and Regenerative Medicine Research Department, Academic Center for Education, Culture and Research (ACECR)-Khorasan Razavi, Mashhad, Iran
Mahdi Mirahmadi - Stem Cells and Regenerative Medicine Research Department, Academic Center for Education, Culture and Research (ACECR)-Khorasan Razavi, Mashhad, Iran
Fatemeh Sadeghifar - Department of Biology, Faculty of science, Hakim Sabzevari University, Sabzevar, Iran
Hamid Reza Bidkhori - Stem Cells and Regenerative Medicine Research Department, Academic Center for Education, Culture and Research (ACECR)-Khorasan Razavi, Mashhad, Iran

Abstract:

     Oxidative stress occurs as a result of breaking down the balance between oxidants (e.g., reactive oxygen species (ROS)) and antioxidants in cells. Several studies have shown that there is a close relationship between oxidative stress and inflammation at the sites of injury. Mesenchymal stem cells (MSCs) are exposed to endogenous and exogenous oxidants generated during their ex vivo expansion or following in vivo transplantation. α-tocopherol (vitamin E) is a fat-soluble compound known for its anti-oxidant and anti-inflammatory properties. In many studies, the immunomodulatory effects of vitamin E have been observed in vivo. This study aimed to determine whether pretreatment of MSCs with antioxidants like vitamin E, will enhance the anti-inflammatory and immunomodulatory properties of these cells. For this purpose, adipose-derived MSCs (ASCs) were treated with vitamin E (۶۰۰ μM) for ۴۸ h. Quantitative PCR (qPCR) experiments were performed to evaluate the expression of genes related to inflammation (IL-۱β, IL-۶, IL-۱۷, IL-۱۰) or immunomodulation (TSG-۶, COX-۲, TDO۲, TGF-β۱). Results indicated that vitamin E significantly increased the expression of COX-۲, TSG-۶, and IL-۱β genes at the mRNA level compared with the control group, while it significantly decreased IL-۶ and TGF-β expressions. No effect was observed for IL-۱۷, IL-۱۰, and TDO۲ genes. These results suggest that in vitro preconditioning of ASCs with vitamin E may allow the cells to improve their anti-inflammatory and immunoregulatory capacities. Vitamin E pretreatment could lead to the improvement of their therapeutic abilities in conditions that are influenced by oxidative stress.

Keywords:

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This Paper COI Code is JR_JCMR-11-2_007. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1347320/

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Mehrzad, Shadi and Hosseini, Sepideh sadat and Momeni-Moghaddam, Madjid and Farshchian, Moien and Hassanzadeh, Halimeh and Mirahmadi, Mahdi and Sadeghifar, Fatemeh and Bidkhori, Hamid Reza,1399,Vitamin E Pretreatment of Mesenchymal Stem Cells: The Interplay of Oxidative Stress and Inflammation,https://civilica.com/doc/1347320

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