Association between serum ۲۵-hydroxy vitamin D level and menstrual cycle length and regularity: A cross-sectional observational study
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJRM-19-11_004
تاریخ نمایه سازی: 24 آذر 1400
Abstract:
Background: Research examining the role of vitamin D deficiency and the development of menstrual disorders in women is of widespread interest. Studies have been published showing that supplementation with high-dose vitamin D can lead to the restoration of the menstrual cycle. We lack adequate information regarding the effect of vitamin D levels on the physiology of menstruation and further on fertility in women of reproductive age due to the contradictory results reported by studies.
Objective: To study the association of ۲۵-hydroxy vitamin D with menstrual cycle characteristics including long and short cycle length and cycle irregularity.
Materials and Methods: In this cross-sectional study, serum vitamin D level of ۱۶۶ women attending an outpatient department with menstrual irregularities after excluding all obvious causes of menstrual disorders (n = ۸۳) between April-June ۲۰۱۹ were measured and were compared with women of similar profiles with complaints other than menstrual irregularities (n = ۸۳).
Results: A decreased level of vitamin D was associated with a ۱۳.۳ times odds of an irregular cycle (OR (۹۵% CI): ۱۳.۳۰ (۵.۷۹-۳۰.۶۰), p < ۰.۰۰۱). ۲۵-hydroxy vitamin D was not associated with age or body mass index. We found a significant difference (p < ۰.۰۰۱) in mean vitamin D levels among the females with irregular cycles vs. regular cycles.
Conclusion: Vitamin D plays a role in the physiology of reproduction specific to the menstrual cycle and ovulation. Long-term prospective studies assessing the exact cutoff value and the exact dose of supplementation required are needed.
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Authors
Vinita Singh
Obstetrics and Gynecology Department, Aiims, Raipur, India.
Neelam Tamar
Obstetrics and Gynecology Department, Aiims, Raipur, India.
Zamir Lone
Obstetrics and Gynecology Department, Aiims, Raipur, India.
Esha Das
Obstetrics and Gynecology Department, Aiims, Raipur, India.
Rajshree Sahu
Obstetrics and Gynecology Department, Aiims, Raipur, India.
Sagarika Majumdar
Obstetrics and Gynecology Department, Aiims, Raipur, India.
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