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Title

The effect of curcumin on embryonic in vitro development in experimental polycystic ovary syndrome: An experimental study

مجله طب تولید مثل ایران، دوره: 19، شماره: 11
Year: 1400
COI: JR_IJRM-19-11_006
Language: EnglishView: 50
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Authors

Yousef Nasiri Bari - Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Vahab Babapour - Department of Basic Sciences, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran.
Abbas Ahmadi - Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Morteza Zendehdel Kheybari - Department of Basic Sciences, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran.
Ghasem Akbari - Department of Clinical Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Abstract:

Background: Polycystic ovary syndrome (PCOS) is a common disease in women. Some plant compounds which have antioxidant properties, such as curcumin, may be useful for these patients when delivered orally or in vitro. Objective: The aim of this study was to evaluate the impact of PCOS on oocyte quality and the effect of curcumin on in vitro fertilization of oocytes. Materials and Methods: In this experimental study, naval medical research institute (NMRI) mice aged six to eight wk were used. Mice were divided into five experimental groups (control, experimental PCOS, curcumin ۶, ۱۲ and ۲۴ μM). To induce experimental PCOS, estradiol valerate (۱۰۰ mg/kg, IP) was injected. The total antioxidant capacity and production of malondialdehyde in ovarian tissue and blood serum were evaluated in all groups. Finally, ۶, ۱۲ and ۲۴ μM of curcumin were added to the culture medium of the PCOS group oocytes and development in the different groups was evaluated. Results: A high percentage of oocytes for fertilization were not in good condition in terms of number and quality in the group of PCOS. The addition of curcumin to the embryo culture medium was associated with a higher percentage of fertilized oocytes, two-cells and blastocysts. This increase was significant at a concentration of ۲۴ μM (p ≤ ۰.۰۰۱). Conclusion: Adding curcumin to improve fetal growth and prevent the harmful effects of oxygen free radicals on the culture medium, it is recommended to add a certain concentration of curcumin under normal conditions without oxidative stress (OS).

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Nasiri Bari, Yousef and Babapour, Vahab and Ahmadi, Abbas and Zendehdel Kheybari, Morteza and Akbari, Ghasem,1400,The effect of curcumin on embryonic in vitro development in experimental polycystic ovary syndrome: An experimental study,https://civilica.com/doc/1349331

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The specifications of the publisher center of this Paper are as follows:
Type of center: Azad University
Paper count: 37,210
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