Publisher of Iranian Journals and Conference Proceedings

Please waite ..
Publisher of Iranian Journals and Conference Proceedings
Login |Register |Help |عضویت کتابخانه ها
Paper
Title

Promethazine-HCl determination via CFIA-NAG-ADF-۳۰۰-۲ instrument using phosphomolybdic acid as a precipitating reagent

نشریه آسیایی شیمی سبز، دوره: 5، شماره: 4
Year: 1400
COI: JR_AJGC-5-4_007
Language: EnglishView: 33
This Paper With 17 Page And PDF Format Ready To Download

Buy and Download

با استفاده از پرداخت اینترنتی بسیار سریع و ساده می توانید اصل این Paper را که دارای 17 صفحه است به صورت فایل PDF در اختیار داشته باشید.
آدرس ایمیل خود را در کادر زیر وارد نمایید:

Authors

Nagham S. Turkey - Department of Chemistry, College of Science, University of Baghdad, AL-Jadria, Baghdad, IRAQ
Ghadah Fadhel - Department of Chemistry, College of Science, University of Baghdad, AL-Jadria, Baghdad, IRAQ

Abstract:

In this work, a highly accurate and sensitive method with low cost analyzer NAG/ADF/(۳۰۰-۲) homemade instrument coupled under continuous flow injection (CFIA) analysis was used to determine  promethazine hydrochloride in pure and pharmaceutical drug tablets. This method is dependent on the reaction between promethazine hydrochloride and phosphomolybdic acid (PMA) in the presence of ammonium chloride to form a brownish-yellowish ion-pair complex as precipitate. The turbidity of the formed complex has measured at an angle of ۰-۱۸۰° through the attenuation of incident light by precipitating. The chemical and physical parameters have been studied and optimized to enhance the sensitivity for the developed method of the promethazine hydrochloride-PMA-NH۴Cl system. The calibration curve of the proposed method was linear over the range ۰.۵-۳۰ mmole.L-۱ for both cells (Cell no.۱ and Cell no.۲), the detection limit for cell A = ۲.۱۶۵۹ µg/sample and for cell B = ۰.۴۳۳۲ µg/sample from the visual evaluation of the lowest concentration at which the analyte can be reliably detected with the correlation coefficient (r) = ۰.۹۹۸۴, ۰.۹۹۹۷ for cell A and cell B, respectively. For promethazine-HCl concentrations (۵ and ۱۰ mmole.L-۱) for both cells (n=۸), the relative standard deviation percent (RSD%) was lower than ۰.۵%. The method has been successfully applied for the promethazine HCl determination in two pharmaceutical medicines. A comparison was made using the standard addition curve between the newly proposed method (NAG-ADF-۳۰۰-۲ analyzer) and the reference methods, mainly British Pharmacopoeia (B.P), turbidimetry, and UV- spectrophotometry (λmax =۲۴۹ nm) using paired t-test. It was noticed that there was no significant difference between the methods at ۹۵% confidence level. The statistical procedures have shown that a homemade NAG/ADF/(۳۰۰-۲) analyzer which contains two identical detections units ( cell A and cell B) is the best choice with an excellent prolonged detection, widespread application and extra sensitive.

Keywords:

Paper COI Code

This Paper COI Code is JR_AJGC-5-4_007. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1351226/

How to Cite to This Paper:

If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Turkey, Nagham S. and Fadhel, Ghadah,1400,Promethazine-HCl determination via CFIA-NAG-ADF-۳۰۰-۲ instrument using phosphomolybdic acid as a precipitating reagent,https://civilica.com/doc/1351226

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :

  • Xiao P., Wu W., Yu J., Zhao F. Int. J. ...

Research Info Management

Certificate | Report | من نویسنده این مقاله هستم

اطلاعات استنادی این Paper را به نرم افزارهای مدیریت اطلاعات علمی و استنادی ارسال نمایید و در تحقیقات خود از آن استفاده نمایید.

Share this page

More information about COI

COI stands for "CIVILICA Object Identifier". COI is the unique code assigned to articles of Iranian conferences and journals when indexing on the CIVILICA citation database.

The COI is the national code of documents indexed in CIVILICA and is a unique and permanent code. it can always be cited and tracked and assumed as registration confirmation ID.

Support