The effect of gamma radiation on plasma levels of zinc and selenium in nuclear medicine staff

Background and aims: Gamma radiation is widely being used in medical-imaging centers. The aim of this study was to measure possiblealterations in serum zinc and selenium levels among nuclear medicine staff.Methods: This cross-sectional study was carried out on ۳۰ nuclear medicine staff as well as on ۱۰ individuals as the control group.Blood samples (۲۰ mL) were obtained from the participants and the serum specimens were isolated by centrifugation at ۴۰۰۰ rpm for ۷minutes. The samples were then used for measurement of zinc and selenium levels. Zinc and selenium levels were measured using atomicabsorption spectroscopy (AAS) with a graphite furnace. The mean serum levels of zinc and selenium were compared using SPSS.Results: The mean level of zinc in the radiated group (۷۰.۹۱±۱۴.۴۶ μmol/L) was significantly lower than that in the control group(۸۹.۷۵±۱۷.۳۵ μmol/L) (P = ۰.۰۰۲). A negative significant correlation was found between the duration of exposure to radiation and zinclevels (P = ۰.۰۰۵). Furthermore, a negative significant relationship was observed between the mean radiation dose after ۵ years and zincconcentration (P = ۰.۰۱۹). Non-significant difference was found in the mean level of selenium between control (۱.۷۱±۰.۳۵ μmol/L) andradiation (۲.۱۳±۱.۱۲ μmol/L) groups. Furthermore, no significant correlation was found between selenium level and exposure time.Conclusion: Based on the results, declined level of zinc can be considered as one of the possible mechanisms caused by gamma radiationon cells which may be associated with oxidative damage. Therefore, zinc therapy can be helpful for those who work at medical radiationcenters; however, it merits further studies.

Keywords:

Gamma , Serum , Zinc , Selenium