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Title

In vitro effect of iron chelators on the growth of Escherichia coli, Staphylococcus epidermidis, Staphylococcus aureus, Yersinia enterocolitica, and Pseudomonas aeruginosa Strains

مجله دانشگاه علوم پزشکی شهرکرد، دوره: 21، شماره: 5
Year: 1398
COI: JR_SKUMS-21-5_008
Language: EnglishView: 28
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Authors

Kiavash Fekri - Assistant Professor, Department of Pediatrics, Shahrekord University of Medical Sciences, Shahrekord, Iran
Abolfazl Khoshdel - Professor, Clinical Biochemistry Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
Maryam Rasoulynezhad - MD, Shahrekord University of Medical Sciences, Shahrekord, Iran
Soleiman Kheiri - Associate Professor, Clinical Biochemistry Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
Afsaneh Malekpour - Assistant Professor, Department of Community Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
Behnam Zamanzad - Assistant Professor, Department of Microbiology and Immunology, Shahrekord University of Medical Sciences, Shahrekord, Iran

Abstract:

Background and aims:Thalassemia patients are predisposed to septicemia due to iron overload. The iron chelators have a potential role inthe treatment of septicemia. This study was conducted to investigate the in vitro effect of iron chelators, deferoxamine (DFO), deferiprone(DFP), and deferasirox (DFS) on the growth of effective bacteria (Staphylococcus aureus, Yersinia enterocolitica, and Pseudomonasaeruginosa) and their synergistic effect with each other and antibiotics.Materials and Methods: Five bacterial strains were incubated in the presence of seven chelators in Mueller Hinton agar and the numberof colonies was recorded for each sample. Antibiotic discs were placed in the plates. Susceptibility to antibiotics was assessed by discdiffusion method (Kirby-Bauer test) and also the zone inhibition around the disc was measured in mm after incubating the relevant plateat ۳۷°C for a day.Results: The growth of all the studied bacteria increased in the presence of iron and was inhibited in the presence of different chelators.Chelators and antibiotics had synergistic effects on growth inhibition of Escherichia coli, S. aureus, and P. aeruginosa in culture medium,while the growth inhibition of Y. enterocolitica was seen in the presence of deferiprone and deferasirox combination.Conclusion: Chelators in combination with antibiotics exert synergistic effects on growth inhibition of prevalent bacteria (except for Y.enterocolitica).

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This Paper COI Code is JR_SKUMS-21-5_008. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1352290/

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Fekri, Kiavash and Khoshdel, Abolfazl and Rasoulynezhad, Maryam and Kheiri, Soleiman and Malekpour, Afsaneh and Zamanzad, Behnam,1398,In vitro effect of iron chelators on the growth of Escherichia coli, Staphylococcus epidermidis, Staphylococcus aureus, Yersinia enterocolitica, and Pseudomonas aeruginosa Strains,https://civilica.com/doc/1352290

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Type of center: علوم پزشکی
Paper count: 1,290
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